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Assessment of photodynamic therapy with annatto and led for the treatment of halitosis in mouth-breathing children: Randomized controlled clinical trial

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Bruno, Laura Hermida ; Mandetta, Amanda Rafaelly Honorio ; Sobral, Ana Paula Taboada ; Goncalves, Marcela Leticia Leal ; Santos, Elaine Marcilio ; Fossati, Ana Laura ; Gallo, Juliana Maria Altavista Sagretti ; Motta, Pamella de Barros ; Deana, Alessandro Melo ; Horliana, Anna Carolina Ratto Tempestini ; Motta, Lara Jansiski ; Ferrari, Raquel Agnelli Mesquita ; Fernandes, Kristianne Porta Santos ; Bussadori, Sandra Kalil
Número total de Autores: 14
Tipo de documento: Artigo Científico
Fonte: PLoS One; v. 19, n. 9, p. 14-pg., 2024-09-03.
Resumo

Objective To assess the effectiveness of antimicrobial photodynamic therapy (aPDT) employing an annatto-based (20%) dye combined with blue LED for the treatment of halitosis in mouth-breathing children. Materials and methods Fifty-two children six to twelve years of age with diagnoses of mouth breathing and halitosis (score of >= 3 on portable breath meter) Breath Alert (TM) (Tanita Corporation (R)-Japan), were randomly allocated to two groups (n = 26). Group 1: brushing, dental floss and aPDT applied to middle third of the dorsum of the tongue. Group 2: brushing, dental floss and tongue scraper. Breath meter results before, immediately after treatment as well as seven and 30 days after treatment were compared. The hypothesis of normality in the data was discarded by the Shapiro-Wilk test (p < 0.05) and for statistical analysis the Wilcoxon and Mann-Whitney tests were used. Results A significant difference was found between the pre-treatment reading and all other readings (p < 0.05) in both groups, suggesting the effectiveness of the proposed treatments. No significant difference was found between the post-treatment reading and two follow-up readings, suggesting the maintenance of the effect of treatment over time (p > 0.05). However, significant differences were found between groups for all post-treatment assessments (p < 0.0001 for all comparisons), indicating greater effectiveness with aPDT. No association was found between the initial reading and the presence of coated tongue. Conclusion Antimicrobial photodynamic therapy using annatto and blue LED proved to be a viable therapeutic option for the treatment of halitosis in mouth-breathing children. (AU)

Processo FAPESP: 19/14229-6 - Estudo comparativo entre a terapia fotodinâmica com urucum e LED e probióticos na redução da halitose: ensaio clínico controlado
Beneficiário:Sandra Kalil Bussadori
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 22/16828-7 - Estudo comparativo entre terapia fotodinâmica com LED e probióticos no tratamento da Halitose: ensaio clínico controlado e randomizado
Beneficiário:Sandra Kalil Bussadori
Modalidade de apoio: Auxílio à Pesquisa - Regular