Molecular mechanisms of cell death by parthanatos: More questions than answers

Autor(es)

de Moura, Rafael Dias ; de Mattos, Priscilla Doria ; Valente, Penelope Ferreira ; Hoch, Nicolas Carlos

• Tipo de documento: Artigo Científico
• Fonte: GENETICS AND MOLECULAR BIOLOGY; v. 47, p. 12-pg., 2024-01-01.

Resumo

Regulated cell death by a non-apoptotic pathway known as parthanatos is increasingly recognised as a central player in pathological processes, including ischaemic tissue damage and neurodegenerative diseases. Parthanatos is activated under conditions that induce high levels of DNA damage, leading to hyperactivation of the DNA damage sensor PARP1. While this strict dependence on PARP1 activation is a defining feature of parthanatos that distinguishes it from other forms of cell death, the molecular events downstream of PARP1 activation remain poorly understood. In this mini-review, we highlight a number of important questions that remain to be answered about this enigmatic form of cell death. (AU)

• Processo FAPESP: 18/18007-5 - ADP-ribosilação de proteínas: sinalização de danos ao DNA e impactos na saúde humana
• Beneficiário: Nicolas Carlos Hoch
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores