| Texto completo | |
| Autor(es): |
Oliveira, Mariana de Araujo
;
de Almeida, Sandro Rogerio
;
Martins, Joilson O.
Número total de Autores: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF FUNGI; v. 10, n. 8, p. 14-pg., 2024-08-01. |
| Resumo | |
Sporotrichosis is a type of zoonotic subcutaneous mycosis caused by different species of dimorphic fungus of the genus Sporothrix, and it is the most common form of subcutaneous mycosis in Latin America. Sporotrichosis is generally restricted to cutaneous and lymphatic tissue (i.e., localized forms), and involvement in the viscera (i.e., disseminated or disseminated cutaneous form) is uncommon, especially in the central nervous system. However, immunosuppression in individuals with diabetes mellitus can lead to the disseminated form of the disease due to a failure to eliminate the pathogen and poor infection treatment outcomes. Possible correlations between patients with diabetes and their greater susceptibility to disseminated cases of sporotrichosis include a decreased cytokine response after stimulation, increased oxidative stress, decreased chemotaxis, phagocytic activity, adhesion and rolling of neutrophils and monocytes/macrophages, and increased macrophage/monocyte and polymorphonuclear cell apoptosis. Therefore, this review highlights novel insights into diabetes and sporotrichosis by investigating how chronic inflammation affects and aggravates the infection, the possible causes of the greater susceptibility of Sporothrix sp. to hematogenous dissemination in immunocompromised patients, and the main alterations that this dissemination can cause. (AU) | |
| Processo FAPESP: | 24/00810-7 - Investigando mecanismos autofágicos na vigência de micose subcutânea causada por Sporotrhix brasiliensis em animais diabéticos |
| Beneficiário: | Joilson de Oliveira Martins |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 22/07100-0 - Avaliação do processo autofágico em macrófagos e linfócitos em micoses sistêmicas causadas por Paracoccidioides brasiliensis em animais sadios e diabéticos |
| Beneficiário: | Mariana de Araujo Oliveira |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |
| Processo FAPESP: | 22/00482-4 - Investigando mecanismos autofágicos em camundongos com senescência acelerada |
| Beneficiário: | Joilson de Oliveira Martins |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |