Furan-based polymer: evaluating the cytogenotoxic profile from starting materials to the final product

Autor(es)

dos Santos, Isabela Caroline ; da Silva, Lucas Henrique Domingos ; Paris Junior, Jose Alberto ; Dorm, Bruna Carolina ; Trovatti, Eliane ; Resende, Flavia Aparecida

• Tipo de documento: Artigo Científico
• Fonte: POLYMER BULLETIN; v. 81, n. 15, p. 17-pg., 2024-06-24.

Resumo

Polymers derived from renewable sources, particularly those based on furan, have attracted significant attention within the scientific community due to their potential as an ecologically viable alternative, aiming to minimize the negative impacts arising from the accumulation of plastics derived from fossil hydrocarbons. However, few toxicogenetic studies have been conducted. Therefore, the objective of this study was to assess the cytotoxicity and mutagenicity of starting materials (hexamethylenediamine, maleic anhydride, furan and furan maleic anhydride adduct), as well as a new polymer derived from the furan maleic anhydride adduct. Hexamethylenediamine, maleic anhydride, and furan maleic anhydride adduct exhibited comparable cytotoxic profiles, whereas furan demonstrated lower cytotoxic potential (IC50 of 72.94 +/- 2.49 mg/mL), yet it was the only reagent capable of inducing mutagenicity. Furan's mutagenic activity by Ames test was observed in the TA100 strain, both with and without metabolization. The polymer, in turn, exhibited low cytotoxic effect (cell viability exceeding 70%) and demonstrated non-mutagenicity under the experimental conditions, emphasizing its safety concerning toxicological risks. In conclusion, this study contributes to the genotoxicological safety assessment of starting materials, and a new polymer sourced from renewable origins. The absence of mutagenicity and the low cytotoxic potential of the assessed samples contribute to the battery of tests required to indicate safe applications, thereby fostering acceptance, and minimizing associated risks. Among the evaluated reagents, special caution is warranted in handling furan due to its potential to induce gene mutations. (AU)

• Processo FAPESP: 17/18782-6 - Plataforma click chemistry aplicada ao desenvolvimento de materiais poliméricos para uso em medicina regenerativa
• Beneficiário: Eliane Trovatti
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 22/02118-8 - Análise da citotoxicidade e mutagenicidade de materiais de partida e de um novo polímero a base de furano
• Beneficiário: Isabela Caroline dos Santos
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 17/16278-9 - Estudo do potencial genotoxicológico e da permeabilidade em células Caco-2 de complexos metálicos com promissoras atividades biológicas
• Beneficiário: Flávia Aparecida Resende Nogueira
• Modalidade de apoio: Auxílio à Pesquisa - Regular