Lipid metabolism and neuromuscular junction as common pathways underlying the genetic basis of erectile dysfunction and obstructive sleep apnea

Autor(es)

Adami, Luana N. G. ; Moyses-Oliveira, Mariana ; Souza-Cunha, Lais Amanda ; Vasco, Matheus Brandao ; Tufik, Sergio ; Andersen, Monica L.

• Tipo de documento: Artigo Científico
• Fonte: INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH; v. 36, n. 6, p. 7-pg., 2023-11-21.

Resumo

Erectile dysfunction (ED) incidence is higher in patients with obstructive sleep apnea (OSA). Studies have suggested that ED and OSA may activate similar pathways; however, few have investigated the links between their underlying genotypic profiles. Therefore, we conducted an in-silico analysis to test whether ED and OSA share genetic variants of risk and to identify any molecular, cellular and biological interactions between them. Two gene lists were manually curated through a literature review based on a PUBMED search, which resulted in one gene list associated with ED (total of 205 genes) and the other with OSA (total of 2622 genes). Between those gene sets, 35 were common for both lists (Fisher exact test, p-value = 0.027). The Protein-protein interaction (PPI) analysis using the intersect list as input showed that 3 of them had direct interactions (LPL, DGKB and PLCB1). In addition, the biological function of the genes contained in the intersect list suggested that pathways related to lipid metabolism and the neuromuscular junction were commonly found in the genetic basis of ED and OSA. From the shared genes between both conditions, the biological pathways highlighted in this study may serve as preliminary findings for future functional investigations on OSA and ED association. (AU)

• Processo FAPESP: 23/11995-5 - Distúrbios de sono, função sexual e fértil masculina: uma abordagem celular e molecular
• Beneficiário: Luana Nayara Gallego Adami
• Modalidade de apoio: Bolsas no Brasil - Programa Fixação de Jovens Doutores
• Processo FAPESP: 21/09089-0 - Edição genética em larga escala para o estudo de doenças do neurodesenvolvimento em modelos celulares isogênicos
• Beneficiário: Mariana Moysés Oliveira
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 20/13467-8 - Relação da apneia obstrutiva do sono e suas comorbidades com a microbiota intestinal: interface com sexualidade e função reprodutiva
• Beneficiário: Monica Levy Andersen
• Modalidade de apoio: Auxílio à Pesquisa - Temático