Spectrophotometric Determination of Captopril Through Charge Transfer Complex Formation Using Fractional Factorial and Central Composite Design

Autor(es):	Ribeiro, Paulo R. S. ^[1] ; Pezza, Leonardo ^[2] ; Pezza, Helena R. ^[2] ; Tognolli, Joao O. ^[2] Número total de Autores: 4
Afiliação do(s) autor(es):	^[1] Saude & Tecnol UFMA, Ctr Ciencias Sociais, BR-65900000 Imperatriz, MA - Brazil ^[2] Inst Quim UNESP, BR-14801970 Araraquara, SP - Brazil Número total de Afiliações: 2
Tipo de documento:	Artigo Científico
Fonte:	Latin American Journal of Pharmacy; v. 30, n. 6, p. 1158-1166, AUG 2011.
Citações Web of Science:	2
Resumo
A new spectrophotometric method was developed for the determination of captopril (n donor) through charge transfer complex formation with p-chloranil (pi acceptor). The different experimental parameters that affect the absorbance intensity were carefully studied. Thus, these parameters were optimized using chemometric methods of fractional factorial and central composite design. At the optimum reaction conditions, the rectilinear calibration graphs were obtained in the concentration range 1.86 x 10(-4) to 738 x 10(-4) mol/L captopril with an excellent correlation coefficient (r = 0.9996). The proposed procedure could be applied successfully for the determination of the investigated drug in their pharmaceutical dosage forms with a good precision and accuracy compared to official and reported method as revealed by F- and t-tests at 95 % confidence level. No interference was observed from common excipients in formulations. (AU)