Sleep and muscle recovery: Endocrinological and molecular basis for a new and promising hypothesis

Autor(es)

Dattilo, M. ^[1] ; Antunes, H. K. M. ^{[1, 2]} ; Medeiros, A. ^[2] ; Monico Neto, M. ^[1] ; Souza, H. S. ^[1] ; Tufik, S. ^[3] ; de Mello, M. T. ^{[3, 1]}

Afiliação do(s) autor(es)

^[1] CEPE, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Dept Biociencias, Santos - Brazil

^[3] Univ Fed Sao Paulo, Dept Psicobiol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Medical Hypotheses; v. 77, n. 2, p. 220-222, AUG 2011.
• Citações Web of Science: 66

Resumo

Sleep is essential for the cellular, organic and systemic functions of an organism, with its absence being potentially harmful to health and changing feeding behavior, glucose regulation, blood pressure, cognitive processes and some hormonal axes. Among the hormonal changes, there is an increase in cortisol (humans) and corticosterone (rats) secretion, and a reduction in testosterone and Insulin-like Growth Factor 1, favoring the establishment of a highly proteolytic environment. Consequently, we hypothesized that sleep debt decreases the activity of protein synthesis pathways and increases the activity of degradation pathways, favoring the loss of muscle mass and thus hindering muscle recovery after damage induced by exercise, injuries and certain conditions associated with muscle atrophy, such as sarcopenia and cachexia. (C) 2011 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 09/11056-1 - Efeitos da privação de sono no processo de recuperação muscular
• Beneficiário: Murilo Dattilo
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 98/14303-3 - Center for Sleep Studies
• Beneficiário: Sergio Tufik
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs