Host metabolomic responses in recurrent P. vivax malaria

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Yakubu, Michael N. ; Mwangi, Victor I. ; Netto, Rebeca L. A. ; Alecrim, Maria G. C. ; Alves, Jessica R. S. ; Almeida, Anne C. G. ; Santos, Gabriel F. ; Lima, Gesiane S. ; Machado, Lucas S. ; Koolen, Hector H. F. ; Guimaraes, Tiago P. ; Chaves, Andrea R. ; Vaz, Boniek G. ; Monteiro, Wuelton M. ; Costa, Fabio T. M. ; Lacerda, Marcus V. G. ; Gardinassi, Luiz G. ; de Melo, Gisely C.

• Tipo de documento: Artigo Científico
• Fonte: SCIENTIFIC REPORTS; v. 14, n. 1, p. 13-pg., 2024-03-27.

Resumo

Malaria is the leading parasitic disease worldwide, with P. vivax being a major challenge for its control. Several studies have indicated metabolomics as a promising tool for combating the disease. The study evaluated plasma metabolomic profiles of patients with recurrent and non-recurrent P. vivax malaria in the Brazilian Amazon. Metabolites extracted from the plasma of P. vivax-infected patients were subjected to LC-MS analysis. Untargeted metabolomics was applied to investigate the metabolic profile of the plasma in the two groups. Overall, 51 recurrent and 59 non-recurrent patients were included in the study. Longitudinal metabolomic analysis revealed 52 and 37 significant metabolite features from the recurrent and non-recurrent participants, respectively. Recurrence was associated with disturbances in eicosanoid metabolism. Comparison between groups suggest alterations in vitamin B6 (pyridoxine) metabolism, tyrosine metabolism, 3-oxo-10-octadecatrienoate beta-oxidation, and alkaloid biosynthesis II. Integrative network analysis revealed enrichment of other metabolic pathways for the recurrent phenotype, including the butanoate metabolism, aspartate and asparagine metabolism, and N-glycan biosynthesis. The metabolites and metabolic pathways predicted in our study suggest potential biomarkers of recurrence and provide insights into targets for antimalarial development against P. vivax. (AU)

• Processo FAPESP: 23/01208-6 - Desenvolvimento de novas ferramentas para busca e validação de alvos moleculares para terapia contra Plasmodium vivax
• Beneficiário: Jéssica Rafaela dos Santos Alves
• Modalidade de apoio: Bolsas no Brasil - Programa Capacitação - Treinamento Técnico
• Processo FAPESP: 21/14014-0 - Estudo comparativo sobre nichos do Plasmodium vivax com ênfase na medula óssea e sangue periférico e seus papéis na infecção e patologia deste parasita
• Beneficiário: Jéssica Rafaela dos Santos Alves
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 17/18611-7 - Desenvolvimento de novas ferramentas para busca e validação de alvos moleculares para terapia contra Plasmodium vivax
• Beneficiário: Fabio Trindade Maranhão Costa
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 21/04632-8 - MRC-FAPESP: definindo a função do reservatório hematopoiético de parasitas na infecção e patologia causadas por Plasmodium vivax
• Beneficiário: Fabio Trindade Maranhão Costa
• Modalidade de apoio: Auxílio à Pesquisa - Regular