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Neuropathic pain, mood, and stress-related disorders: A literature review of comorbidity and co-pathogenesis

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Autor(es):
Vieira, Willians Fernando ; Coelho, David Richer Araujo ; Litwiler, Scott Thomas ; McEachern, Kayla Marie ; Clancy, Julie A. ; Morales-Quezada, Leon ; Cassano, Paolo
Número total de Autores: 7
Tipo de documento: Artigo Científico
Fonte: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS; v. 161, p. 11-pg., 2024-04-20.
Resumo

Neuropathic pain can be caused by multiple factors, and its prevalence can reach 10 % of the global population. It is becoming increasingly evident that limited or short-lasting response to treatments for neuropathic pain is associated with psychological factors, which include psychiatric comorbidities known to affect quality of life. It is estimated that 60 % of patients with neuropathic pain also experience depression, anxiety, and stress symptoms. Altered mood, including stress, can be a consequence of several painful conditions but can also favor pain chronicization when preexisting. Despite the apparent tight connection between clinical pain and mood/stress disorders, the exact physiological mechanisms remain unclear. This review aims to provide an overview of stateof-the-art research on the mechanisms of pain related to the pathophysiology of depression, anxiety, and stress disorders. (AU)

Processo FAPESP: 19/21158-8 - Estudo dos efeitos da fotobiomodulação sobre o metabolismo mitocondrial de neurônios aferentes primários do gânglio da raiz dorsal em modelo de Neuropatia Diabética Periférica
Beneficiário:Willians Fernando Vieira
Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 21/10982-1 - Influência da fotobiomodulação transcraniana no infravermelho próximo sobre o fluxo sanguíneo cerebral avaliado por ressonância magnética funcional (BOLD) em pacientes com transtorno depressivo maior (TDM)
Beneficiário:Willians Fernando Vieira
Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado