| Texto completo | |
| Autor(es): Mostrar menos - |
Nakahata, Douglas H.
;
Corsino, Carlos E. S. P.
;
de Morais, Guilherme C.
;
Pereira, Gabriele M.
;
Cruz, Allefe B.
;
Pereira, Douglas Henrique
;
Cassani, Natasha M.
;
Ruiz, Uriel Enrique A.
;
Santos, Igor A.
;
Jardim, Ana Carolina G.
;
Corbi, Pedro P.
Número total de Autores: 11
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Journal of the Brazilian Chemical Society; v. 35, n. 11, p. 12-pg., 2024-01-01. |
| Resumo | |
This study presents the synthesis and characterization of five Schiff bases derived from the reaction of 4-(2-aminoethyl)-benzenesulfonami de (compound 1 ) with corresponding aldehydes, (benzaldehyde, 2-pyridinecarboxaldehyde, 2-quinolinecarboxaldehyde, 8-hydroxy2-quinolinecarboxaldehyde and 4-imidazolecarboxaldehyde, for compounds 2- 6 , respectively). Characterization was performed by various spectroscopic techniques and supported by density functional theory (DFT) calculations. The crystal structures revealed how the substituent groups influenced the present supramolecular interactions. Compounds 1- 4 and 6 showed no cytotoxicity to BHK-21 and VERO E6 cells at the highest concentration of 50 mu mol L-1,-1 , while compound 5 was cytotoxic at this concentration. Compound 5 was active against the Chikungunya virus at the concentration of 10 mu mol L-1,-1 , highlighting the effect of the 8-hydroxyquinoline substituent for the antiviral activity. For Zika virus, compound 6 was the only one active at 50 mu mol L-1.-1 . The results suggest the potential of combining sulfonamides with other chemotypes for further development of antiviral agents, especially in the treatment of arboviral diseases. (AU) | |
| Processo FAPESP: | 21/10265-8 - Centro de Inovação Teranóstica em Câncer (CancerThera) |
| Beneficiário: | Carmino Antonio de Souza |
| Modalidade de apoio: | Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs |
| Processo FAPESP: | 13/08293-7 - CECC - Centro de Engenharia e Ciências Computacionais |
| Beneficiário: | Munir Salomao Skaf |
| Modalidade de apoio: | Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs |
| Processo FAPESP: | 15/20882-3 - Complexos metálicos com sulfametoxidiazina e sulfadimetoxina: síntese, caracterização e aplicações como agentes antimicrobianos para uso tópico |
| Beneficiário: | Douglas Hideki Nakahata |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 17/11485-6 - Desenvolvimentos computacionais e teóricos baseados em métodos ab initio e na Teoria do Funcional de Densidade |
| Beneficiário: | Rogério Custodio |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |