Obesity as an aggravating factor of systemic lupus erythematosus disease: What we already know and what we must explore? - A rapid scoping review

Autor(es)

Carvalho, Lucas M. ; Carvalho, Beatriz G. ; Souza, Leticia L. ; da Mota, Jhulia C. N. L. ; Ribeiro, Amanda A. ; Nicoletti, Carolina F.

• Tipo de documento: Artigo Científico
• Fonte: NUTRITION; v. 128, p. 10-pg., 2024-09-07.

Resumo

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can affect various organs and systems. Symptoms of SLE can vary widely from person to person and over time, including fatigue, joint pain, skin rashes, fever, and inflammation of multiple organs. The association between SLE and excess body weight has been the subject of study, with evidence suggesting that overweight and obesity can worsen the disease's clinical presentation. Obesity is linked to a state of low-grade chronic inflammation, which can exacerbate the inflammation present in SLE. Additionally, obesity may negatively impact treatment response, disease progression, and patient prognosis. Patients with SLE and obesity may face additional challenges in managing the disease, such as increased symptom severity, higher risk of cardiovascular and renal complications, and a reduced response to conventional treatments. Obesity can also influence the quality of life of patients with SLE, making a holistic approach that considers the individual's nutritional status essential. Therefore, understanding the relationship between obesity and SLE is crucial for optimizing treatment, improving clinical outcomes, and enhancing patients' quality of life. Further research is needed to elucidate the underlying pathophysiological mechanisms, develop more precise and personalized management strategies, and identify biomarkers that can predict disease prognosis and treatment response. (c) 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies. (AU)

• Processo FAPESP: 21/09777-4 - Pacientes com lúpus e obesidade apresentam alteração do perfil de metilação dos genes inflamatórios? Estudo transversal
• Beneficiário: Lucas de Moura Carvalho
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 21/09745-5 - Efeitos da suplementação de nutrientes doadores de metil no perfil de metilação de genes inflamatório em pacientes com lúpus e obesidade: estudo clínico randomizado
• Beneficiário: Jhulia Caroline Nunes Leal da Mota
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 20/01893-2 - Progressos em estudos epigenéticos nas doenças reumáticas auto-imunes: da bancada à clínica no Lupus Eritematoso Sistêmico
• Beneficiário: Carolina Nicoletti Ferreira Fino
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 20/15126-3 - Progressos em estudos epigenéticos nas doenças reumáticas auto-imunes: da bancada à clínica no Lupus eritematoso sistêmico
• Beneficiário: Carolina Nicoletti Ferreira Fino
• Modalidade de apoio: Bolsas no Brasil - Jovens Pesquisadores