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Recovery of the baroreflex and autonomic modulation after anesthesia with MS-222 in bullfrogs

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Autor(es):
Neto, Antonio V. G. S. ; Filogonio, Renato ; Leite, Cleo A. C.
Número total de Autores: 3
Tipo de documento: Artigo Científico
Fonte: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY; v. 295, p. 5-pg., 2024-05-15.
Resumo

The time course for recovery after anesthesia is poorly described for tricaine methanesulfonate (MS-222). We suggest that the baroreflex and the heart rate variability (HRV) could be used to index the recovery of the autonomic modulation after anesthesia. We analyzed the recovery profile of behavioral and physiological parameters over time to analyze the progression of recovery after anesthesia of American bullfrogs with MS-222. Mean heart rate stabilized after 17 h, whereas the baroreflex efficiency index took 23 h and the baroreflex operating gain, 29 h. Mean arterial pressure recovered after 26 h. Power spectral density peaked at 23 h and again after 40 h. Baroreflex was a relevant component of the first phase of HRV, while autonomic modulation for resting may take longer than 40 h. We suggest that physiological recovery is a complex phenomenon with multiple progressive phases, and the baroreflex may be a useful tool to observe the first substantial recovery of post-instrumentation capacity for autonomic modulation. (AU)

Processo FAPESP: 18/05035-0 - Ajustes cardiovasculares em Squamata: validação do modelo da cascavel descerebrada para estudos de mecanismos regulatórios cardiovasculares
Beneficiário:Cléo Alcantara Costa Leite
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 16/20158-6 - Adaptações morfofuncionais cardiovasculares para a relação alométrica entre pressão arterial e massa em répteis
Beneficiário:Renato Filogonio
Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado