| Texto completo | |
| Autor(es): |
Hollanda, Luciana M.
[1]
;
Cury, Gisele C. G.
[1]
;
Pereira, Rafaella F. C.
[1]
;
Ferreira, Gracielle A.
[2]
;
Sousa, Andreza
[2]
;
Sousa, Edesia M. B.
[2]
;
Lancellotti, Marcelo
[1]
Número total de Autores: 7
|
| Afiliação do(s) autor(es): | [1] State Univ Campinas UNICAMP, Dept Biochem, Inst Biol CP6109, BR-13083970 Campinas, SP - Brazil
[2] Ctr Dev Nucl Energy, Nanotechnol Serv, Nat Commiss Nucl Energy, BR-30123970 Belo Horizonte, MG - Brazil
Número total de Afiliações: 2
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF NANOBIOTECHNOLOGY; v. 9, JUL 25 2011. |
| Citações Web of Science: | 9 |
| Resumo | |
Background: This study aimed the use of mesoporous silica under the naturally transformable Neisseria meningitidis, an important pathogen implicated in the genetic horizontal transfer of DNA causing a escape of the principal vaccination measures worldwide by the capsular switching process. This study verified the effects of mesoporous silica under N. meningitidis transformation specifically under the capsular replacement. Methods: we used three different mesoporous silica particles to verify their action in N. meningitis transformation frequency. Results: we verified the increase in the capsular gene replacement of this bacterium with the three mesoporous silica nanoparticles. Conclusion: the mesouporous silica particles were capable of increasing the capsule replacement frequency in N. meningitidis. (AU) | |
| Processo FAPESP: | 08/56777-5 - Estudo molecular e profilático das bactérias naturalmente transformaveis do trato respiratório humano - Haemophilus influenzae, Neisseria meningitidis e Streptococcus pneumoniae |
| Beneficiário: | Marcelo Lancellotti |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |