| Full text | |
| Author(s): |
Hollanda, Luciana M.
[1]
;
Cury, Gisele C. G.
[1]
;
Pereira, Rafaella F. C.
[1]
;
Ferreira, Gracielle A.
[2]
;
Sousa, Andreza
[2]
;
Sousa, Edesia M. B.
[2]
;
Lancellotti, Marcelo
[1]
Total Authors: 7
|
| Affiliation: | [1] State Univ Campinas UNICAMP, Dept Biochem, Inst Biol CP6109, BR-13083970 Campinas, SP - Brazil
[2] Ctr Dev Nucl Energy, Nanotechnol Serv, Nat Commiss Nucl Energy, BR-30123970 Belo Horizonte, MG - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | JOURNAL OF NANOBIOTECHNOLOGY; v. 9, JUL 25 2011. |
| Web of Science Citations: | 9 |
| Abstract | |
Background: This study aimed the use of mesoporous silica under the naturally transformable Neisseria meningitidis, an important pathogen implicated in the genetic horizontal transfer of DNA causing a escape of the principal vaccination measures worldwide by the capsular switching process. This study verified the effects of mesoporous silica under N. meningitidis transformation specifically under the capsular replacement. Methods: we used three different mesoporous silica particles to verify their action in N. meningitis transformation frequency. Results: we verified the increase in the capsular gene replacement of this bacterium with the three mesoporous silica nanoparticles. Conclusion: the mesouporous silica particles were capable of increasing the capsule replacement frequency in N. meningitidis. (AU) | |