| Texto completo | |
| Autor(es): |
Bombassaro, Amanda
;
Figueiredo, Julia Marcondes
;
Taborda, Carlos P.
;
Joosten, Leo A. B.
;
Vicente, Vania A.
;
Queiroz-Telles, Flavio
;
Meis, Jacques F.
;
Kischkel, Brenda
Número total de Autores: 8
|
| Tipo de documento: | Artigo Científico |
| Fonte: | MYCOSES; v. 67, n. 1, p. 11-pg., 2024-01-01. |
| Resumo | |
Fungal skin infections are distributed worldwide and can be associated with economic and social traits. The immune response related to skin cells is complex and its understanding is essential to the comprehension of each cell's role and the discovery of treatment alternatives. The first studies of trained immunity (TI) described the ability of monocytes, macrophages and natural killer (NK) cells to develop a memory-like response. However, the duration of TI does not reflect the shorter lifespan of these cells. These conclusions supported later studies showing that TI can be observed in stem and haematopoietic cells and, more recently, also in non-immune skin cells such as fibroblasts, highlighting the importance of resident cells in response to skin disorders. Besides, the participation of less studied proinflammatory cytokines in the skin immune response, such as IL-36 gamma, shed light into a new possibility of inflammatory pathway blockade by drugs. In this review, we will discuss the skin immune response associated with fungal infections, the role of TI in skin and clinical evidence supporting opportunities and challenges of TI and other inflammatory responses in the pathogenesis of fungal skin infections. (AU) | |
| Processo FAPESP: | 20/03532-7 - Investigação da resposta imune treinada de monócitos e macrófagos após exposição à formulação de vacina contra micoses sistêmicas |
| Beneficiário: | Brenda Kischkel |
| Modalidade de apoio: | Bolsas no Exterior - Estágio de Pesquisa - Doutorado Direto |
| Processo FAPESP: | 18/26402-1 - Prospecção de novos epítopos com potencial vacinal no controle da infecção experimental por Histoplasma capsulatum |
| Beneficiário: | Brenda Kischkel |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |