| Texto completo | |
| Autor(es): |
Kloster, Anna K.
;
Adami, Luana N. G.
;
Moyses-Oliveira, Mariana
;
Hachul, Helena
;
Andersen, Monica L.
;
Tufik, Sergio
Número total de Autores: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JORNAL BRASILEIRO DE REPRODUCAO ASSISTIDA; v. 28, n. 4, p. 23-pg., 2024-10-01. |
| Resumo | |
Objective: To establish an interaction network for genes related to premature ovarian insufficiency (POI) and insomnia, and to identify biological processes that connect POI to the physiological clock. Methods: Previously reported lists of genes associated to POI and insomnia were contrasted and their intersection was used as input on protein-protein interaction analyses. POI-associated genes were contrasted with gene expression markers for neural circadian control and enriched pathways among their shared content were dissected. Results: The functional network generated from the intersection between POI and insomnia gene lists pointed to the central nervous system as the most relevant cellular context for this connection. After identifying POI-associated genes that play a role in neural circadian patterns, we observed the disruption of pathways related to the hypothalamic-pituitary-gonadal axis as the major genetic link between ovarian function and circadian neural circuits. Conclusions: These findings highlight neurological mechanisms that support the POI-insomnia interplay. (AU) | |
| Processo FAPESP: | 23/11995-5 - Distúrbios de sono, função sexual e fértil masculina: uma abordagem celular e molecular |
| Beneficiário: | Luana Nayara Gallego Adami |
| Modalidade de apoio: | Bolsas no Brasil - Programa Fixação de Jovens Doutores |
| Processo FAPESP: | 21/09089-0 - Edição genética em larga escala para o estudo de doenças do neurodesenvolvimento em modelos celulares isogênicos |
| Beneficiário: | Mariana Moysés Oliveira |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 20/13467-8 - Relação da apneia obstrutiva do sono e suas comorbidades com a microbiota intestinal: interface com sexualidade e função reprodutiva |
| Beneficiário: | Monica Levy Andersen |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |