Gut Microbiota Resilience Mechanisms Against Pathogen Infection and its Role in Inflammatory Bowel Disease

Autor(es)

Cipelli, Marcella ; da Silva, Eloisa Martins ; Camara, Niels Olsen Saraiva

• Tipo de documento: Artigo Científico
• Fonte: CURRENT CLINICAL MICROBIOLOGY REPORTS; v. 10, n. 4, p. 11-pg., 2023-10-07.

Resumo

Purpose of ReviewAlthough extensive research has been conducted on microbial resilience, numerous unanswered questions persist. In this study, we highlight impactful research that elucidates the diverse mechanisms underlying the resilience of the gut microbiota against pathogen colonization and its implications on gut health and disease.Recent FindingsThe increasing importance of gut microbiota resistance in the context of pathogenic infections has been extensively reported. The establishment of a homeostatic microbiome-host interaction, facilitated by intricate mechanisms originating from both the microbiota and the host, plays a crucial role in fostering resilience. However, pathogens have evolved several evasion strategies that can disrupt healthy microbiota composition, trigger environmental alterations, and induce inflammation, thereby potentially exacerbating inflammatory diseases in the gut.SummaryIn this review, we aim to highlight the significance of different resilience mechanisms during intestinal infections and their potential for modulation to develop new interventions that can effectively ameliorate Inflammatory Bowel Disease (IBD). (AU)

• Processo FAPESP: 20/14388-4 - Sinalização de incretinas na progressão tumoral em modelo experimental de Câncer Colorretal associado à Colite
• Beneficiário: Eloisa Martins da Silva
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 17/05264-7 - Metabolismo celular, microbiota e sistema imune: novos paradigmas na fisiopatologia das doenças renais
• Beneficiário: Niels Olsen Saraiva Câmara
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 18/24350-4 - Caracterização metabólica da população de células T Foxp3+ RORgt+ no modelo experimental de Câncer colorretal associado à Colite
• Beneficiário: Marcella Cipelli
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto