Autor(es)

Kogure, Gislaine Satyko ; Verruma, Carolina Gennari ; Santana, Barbara A. ; Calado, Rodrigo T. ; Ferriani, Rui Alberto ; Furtado, Cristiana Libardi Miranda ; dos Reis, Rosana Maria

• Tipo de documento: Artigo Científico
• Fonte: REPRODUCTIVE SCIENCES; v. 31, n. 6, p. 9-pg., 2024-02-23.

Resumo

Polycystic ovary syndrome (PCOS) is a multifactorial disorder and obesity occurs in 38% to 88% of these women. Although hyperandrogenism may contribute to telomere lengthening, increased body mass index (BMI) is associated with telomere erosion. We sought to compare leukocyte telomere length (LTL) in PCOS women with normal, overweight, and obese BMI. We evaluated the relationship between LTL and clinical variables of PCOS and inflammatory biomarkers independent of BMI. A total of 348 women (243 PCOS and 105 non-PCOS) were evaluated for anthropometric measures, total testosterone, androstenedione, estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), sex hormone-binding globulin (SHBG), free androgen index (FAI), fasting insulin and glycemia, lipid profile, homocysteine, C-reactive protein (CRP) and homeostatic model of insulin resistance (HOMA-IR). LTL was measured by qPCR. The PCOS group presented higher weight, waist circumference, BMI, testosterone, LH, fasting insulin, FAI, and HOMA-IR, and lower E2, SHBG, and fasting glycemia measures compared with the non-PCOS. When stratified by BMI, LTL was increased in all subgroups in PCOS compared to non-PCOS. However, in the PCOS group, LTL was lower in overweight (P = 0.0187) and obese (P = 0.0018) compared to normal-weight women. The generalized linear model showed that BMI, androstenedione, homocysteine, and CRP were associated with telomere biology. Women with PCOS had longer LTL, however, overweight or obesity progressively contributes to telomere shortening and may affect reproductive outcomes of PCOS, while androstenedione may increase LTL. (AU)

• Processo FAPESP: 15/14031-0 - Efeitos do treinamento físico aeróbio nos parametros moleculares, metabólicos, hormonais e composição corporal em mulheres com a síndrome dos ovários policísticos: um ensaio clínico controlado
• Beneficiário: Rosana Maria dos Reis
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 19/17618-3 - Metilação do DNA e inativação do cromossomo X em mulheres com Síndrome do Ovário Policístico submetidas a diferentes protocolos de treinamento físico
• Beneficiário: Rosana Maria dos Reis
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 12/11566-2 - Polimorfismo cag do receptor de andrógenos e comprimento do telômero em pacientes com falência ovariana prematura
• Beneficiário: Rosana Maria dos Reis
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 12/11069-9 - Polimorfismo cag do receptor de andrógenos e comprimento do telômero em pacientes com falência ovariana prematura
• Beneficiário: Cristiana Libardi Miranda Furtado
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado