| Texto completo | |
| Autor(es): Mostrar menos - |
Polez, Ana M. R.
;
Farias, Renan L.
;
de Lima, Andresa A.
;
Lazzarini, Ana Beatriz
;
de Moura, Thales R.
;
Velasques, Jecika M.
;
Souza, Jessica Carolina
;
Rocha, Fillipe V.
;
Lima, Mauro Almeida
;
Ellena, Javier
;
Miranda, Victor Maia
;
Deflon, Victor M.
;
Moreira, Mariete B.
;
Netto, Adelino V. G.
Número total de Autores: 14
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Journal of Molecular Structure; v. 1321, p. 11-pg., 2024-10-05. |
| Resumo | |
In this study, we report the synthesis, characterization and biological studies on new organometallic compounds bearing orthopalladated oximes and 2,6-lutidine. Cyclopalladated compounds of the type [PdCl(C2,N-ox)(lut)] {ox: bzox = benzaldehydeoxime (1), aphox = acetophenoneoxime (2), tetrox = E-alpha-tetralone oxime (3); lut = 2,6-lutidine} have been obtained from the reaction between the suitable [Pd(C2,N-ox)(mu -Cl)]2 precursor with 2,6lutidine. The compounds have been characterized by elemental analyses, infrared (IR) and NMR spectroscopies. The molecular and crystal structures of 1 - 3 have been determined by single-crystal X-ray crystallography. The cytotoxic activity of compounds 1-3 has been evaluated towards breast (MCF-7 and MD-MBA-231) and lung (A549) human cancer cells along with human lung fibroblast (MRC-5). The level of cytotoxicity is dependent on the tested tumour cell line and the type of orthometallated oxime. The binding properties of the model compound 3 on ct-DNA have been studied using UV-Vis titration, circular dichroism and fluorescence spectroscopy. (AU) | |
| Processo FAPESP: | 22/14041-0 - Planejamento e investigação do potencial antitumoral de complexos metálicos contra células metastáticas e/ou quimiorresistentes |
| Beneficiário: | Adelino Vieira de Godoy Netto |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 17/15850-0 - Difração de raios X como ferramenta no desenvolvimento de potenciais fármacos |
| Beneficiário: | Eduardo Ernesto Castellano |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |