| Texto completo | |
| Autor(es): |
Sandrim, Valeria Cristina
;
Luizon, Marcelo Rizzatti
;
Pilan, Eliane
;
Caldeira-Dias, Mayara
;
Coeli-Lacchini, Fernanda Borchers
;
Kors, Georgia
;
Berndt, Iuly
;
Lacchini, Riccardo
;
Cavalli, Ricardo Carvalho
Número total de Autores: 9
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Revista Brasileira de Ginecologia e Obstetrícia; v. 42, n. 8, p. 8-pg., 2020-08-01. |
| Resumo | |
Objective We examined the interaction of polymorphisms in the genes heme oxygenase-1 (HMOX1) and nitric oxide synthase (NOS3) in patients with preeclampsia (PE) as well as the responsiveness to methyldopa and to total antihypertensive therapy. Methods The genes HMOX1 (rs2071746, A/T) and NOS3 (rs1799983, G/T) were genotyped using TaqMan allele discrimination assays (Applied Biosystems, Foster City, CA, USA), and the levels of enzyme heme oxygenase-1 (HO-1) were measured using enzyme-linked immunosorbent assay (ELISA). Results We found interactions between genotypes of the HMOX-1 and NOS3 genes and responsiveness tomethyldopa and that PE genotyped as AT presents lower levels of protein HO-1 compared with AA. Conclusion We found interactions between the HMOX-1 and NOS3 genes and responsiveness to methyldopa and that the HMOX1 polymorphism affects the levels of enzyme HO-1 in responsiveness to methyldopa and to total antihypertensive therapy. These data suggest impact of the combination of these two polymorphisms on antihypertensive responsiveness in PE. (AU) | |
| Processo FAPESP: | 15/20461-8 - Papel do NRF2 e HO-1 em pré-eclâmpsia: estudo de polimorfismos genéticos, fatores circulantes e ensaios in vitro |
| Beneficiário: | Valeria Cristina Sandrim |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |