| Texto completo | |
| Autor(es): |
Sampaio, Maria de Fatima dos Santos
;
de Paiva, Yara Bezerra
;
Sampaio, Tuane Bazanella
;
Pereira, Messias Gonzaga
;
Coimbra, Norberto Cysne
Número total de Autores: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY; v. 134, n. 5, p. 28-pg., 2024-03-13. |
| Resumo | |
Studies have demonstrated the neuroprotective effect of cannabidiol (CBD) and other Cannabis sativa L. derivatives on diseases of the central nervous system caused by their direct or indirect interaction with endocannabinoid system-related receptors and other molecular targets, such as the 5-HT1A receptor, which is a potential pharmacological target of CBD. Interestingly, CBD binding with the 5-HT1A receptor may be suitable for the treatment of epilepsies, parkinsonian syndromes and amyotrophic lateral sclerosis, in which the 5-HT1A serotonergic receptor plays a key role. The aim of this review was to provide an overview of cannabinoid effects on neurological disorders, such as epilepsy, multiple sclerosis and Parkinson's diseases, and discuss their possible mechanism of action, highlighting interactions with molecular targets and the potential neuroprotective effects of phytocannabinoids. CBD has been shown to have significant therapeutic effects on epilepsy and Parkinson's disease, while nabiximols contribute to a reduction in spasticity and are a frequent option for the treatment of multiple sclerosis. Although there are multiple theories on the therapeutic potential of cannabinoids for neurological disorders, substantially greater progress in the search for strong scientific evidence of their pharmacological effectiveness is needed. Therapeutic potential of Cannabis in diseases of the central nervous system. Therapeutic use of cannabinoids in epilepsy, multiple sclerosis and Parkinson's disease. An expanded endocannabinoid system conceptualization based on the complexity of the interaction of phytocannabinoids with cannabinoid receptors and other molecular targets. image (AU) | |
| Processo FAPESP: | 14/11869-0 - EMU concedido no processo 2013/12916-0: aparelho para a neuroestimulação DBS (Thomas mini matrix system - Thomas recording GmbH® - winchester Strasse - Giessen - Germany) |
| Beneficiário: | Renato Leonardo de Freitas |
| Modalidade de apoio: | Auxílio à Pesquisa - Programa Equipamentos Multiusuários |
| Processo FAPESP: | 20/15050-7 - Estudo do papel da sinalização endocanabinoide e endovaniloide no paleoestriado, na atividade do duplo elo conectivo GABAérgico neoestriado-pálido-nigro-tectal durante a organização do medo instintivo de animais confrontados com serpentes |
| Beneficiário: | Norberto Cysne Coimbra |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |