| Texto completo | |
| Autor(es): Mostrar menos - |
de Souza, Aline
;
Scarim, Caue Benito
;
Cotrim, Paulo Cesar
;
Barbosa Junior, Fernando
;
Rocha, Bruno Alves
;
Calixto, Leandro Augusto
;
Correia, Cristiano Jesus
;
Araujo, Gabriel Lima de Barros
;
Lobenberg, Raimar
;
Bou-Chacra, Nadia Araci
;
Breithaupt-Faloppa, Ana Cristina
Número total de Autores: 11
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Nanomedicine; v. 19, n. 4, p. 9-pg., 2024-01-25. |
| Resumo | |
Background: Leishmaniasis, caused by the protozoan Leishmania sp., infects phagocyte cells present in lymphatic organs. This study demonstrates the influence of nanostructured lipid carrier-loaded hydroxymethylnitrofurazone (NLC-NFOH) on lymphatic uptake using a chylomicron-blocking flow model in rats. Method: Lymphatic uptake of NFOH was assessed 1 h after oral administration of dimethyl sulfoxide with NFOH or NLC-NFOH with and without cycloheximide pretreatment. Result: Dimethyl sulfoxide with NFOH and NLC-NFOH showed NFOH serum concentrations of 0.0316 and 0.0291 mu g/ml, respectively. After chylomicron blocking, NFOH was not detected. Conclusion: Despite log P below 5, NFOH was successfully taken up by the lymphatic system. Long-chain fatty acids and particle size might be main factors in these findings. NLC-NFOH is a promising and convenient platform for treating leishmaniasis via oral administration. (AU) | |
| Processo FAPESP: | 17/08332-3 - Sistemas nanoestruturados com potencial aplicação no tratamento de doenças negligenciadas |
| Beneficiário: | Nádia Araci Bou-Chacra |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |