| Texto completo | |
| Autor(es): |
Palmeira-Mello, Marcos, V
;
Teixeira, Tamara
;
de Melo, Matheus Reis Santos
;
Nicolella, Heloiza Diniz
;
Dutra, Jocely L.
;
Cominetti, Marcia R.
;
Rocha, Fillipe Vieira
;
Tavares, Denise Crispim
;
Batista, Alzir A.
Número total de Autores: 9
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Journal of Inorganic Biochemistry; v. 265, p. 10-pg., 2025-01-04. |
| Resumo | |
Ovarian cancer represents a leading cause of cancer-related deaths in women worldwide. Chemotherapeutic agents are usually employed to treat the patients, and Ruthenium(II)-based compounds have been investigated as possible substitutes for platinum drugs. In this work, we studied three different Ru(II)-phosphine-mercapto complexes (1-3) as potential cytotoxic agents against A2780 and A2780-cisR ovarian cancer cells. A time- dependent cytotoxicity was observed for 2 , which also exhibited better selectivity than cisplatin control. A similar cytotoxic behavior was observed on 3D tumor spheroids. Although no changes were observed in cell cycle distribution, compound 2 affected the mitochondrial membrane potential on A2780 cells, and caused cell death via apoptotic pathway, which was confirmed by flow cytometry assay. Western blotting experiments revealed that 2 affected the expression of p53, PCNA, gamma H2AX and cleaved caspase-3, making it a promising anticancer agent for ovarian cancer. (AU) | |
| Processo FAPESP: | 22/02876-0 - Avaliação do perfil biológico de complexos de coordenação: uma abordagem em modelos celulares 2D e 3D |
| Beneficiário: | Fillipe Vieira Rocha |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 21/01787-0 - Estudo in vitro e in vivo de complexos fosfínicos de Ru(II) com atividades anticancerígenas |
| Beneficiário: | Marcos Vinícius Palmeira de Mello |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 23/02475-8 - Complexos fosfínicos de Ru(II) com naftoquinonas e derivados: potenciais anticancerígenos, estudos in vitro e in vivo |
| Beneficiário: | Alzir Azevedo Batista |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |