| Texto completo | |
| Autor(es): |
Tomioka, Renato B.
;
Ferreira, Gabriela R. V.
;
Aikawa, Nadia E.
;
Maciel, Gustavo A. R.
;
Soares Junior, Jose M. Soares
;
Baracat, Edmund C.
;
Bonfa, Eloisa
;
da Silva, Ismael Dale Cotrim Guerreiro
;
da Silva, Clovis Almeida
Número total de Autores: 9
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Clinics; v. 80, p. 9-pg., 2025-01-01. |
| Resumo | |
The objective of the present study was to evaluate biochemical quantitative metabolites in peripheral blood serum samples of Juvenile Idiopathic Arthritis (JIA) patients and healthy controls. A cross-sectional study included 33 post-pubertal JIA (21 without and 12 with Methotrexate (MTX) women and 28 age-matched healthy controls. Metabolomic analyses based on targeted electrospray ionization tandem mass spectrometry were used to identify possible biochemical pathway modifications in serum from JIA patients. The mean current age (p = 0.065) was similar in JIA patients and healthy controls. Current MTX use in all subtypes of JIA patients was associated with an increase in concentrations of free carnitine [21.74 (12.7-35.2) vs. 27.49 (14.5-41.3) mu M/L, p = 0.02], suggesting an enhanced mitochondrial metabolism and intestinal absorptive function. In contrast, a decreased mitochondrial metabolism was observed in polyarticular and systemic JIA subtypes, with a decrease of several acylcarnitines' concentrations (p < 0.05). In conclusion, the present study identified a distinctive pattern of serum metabolic signatures in JIA patients under MTX therapy. Our findings indicate that MTX use is associated with a more efficient mitochondrial function. (AU) | |
| Processo FAPESP: | 14/14806-0 - Avaliação da reserva ovariana, anticorpo anti-corpo lúteo, citologia cérvico-vaginal, infecções do trato genital inferior, metabolômica e disfunção ovulatória em mulheres com artrite idiopática juvenil |
| Beneficiário: | Clovis Artur Almeida da Silva |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 15/03756-4 - Avaliação da relevância dos níveis sanguíneos de drogas utilizadas em doenças autoimunes reumatológicas no acompanhamento da segurança, eficácia e aderência à terapêutica |
| Beneficiário: | Eloisa Silva Dutra de Oliveira Bonfá |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |