| Texto completo | |
| Autor(es): |
Dawangpa, Atchara
;
Chitta, Pitaksin
;
Rodrigues, Guilherme da Silva
;
Iadsee, Nutta
;
Noronha, Natalia Y.
;
Nonino, Carla B.
;
Bueno Junior, Carlos R.
;
Sae-Lee, Chanachai
Número total de Autores: 8
|
| Tipo de documento: | Artigo Científico |
| Fonte: | PLoS One; v. 19, n. 12, p. 22-pg., 2024-12-16. |
| Resumo | |
This study examined the effects of a 14-week combined exercise program on blood DNA methylation (DNAm) and its potential biological pathways in normal-weight, overweight, and obese older women. A total of 41 participants were assessed at baseline, 7 weeks, and 14 weeks into the training. Their whole-blood DNAm profiles were measured using the Infinitum MethylationEPIC BeadChip, alongside physical and biochemical health evaluations. The results showed notable health improvements, with decreases in blood pressure and cholesterol levels in the overweight and obese groups. Blood triglycerides were reduced only in the overweight group. Physical performance also improved across all groups. At 14 weeks, 1,043 differentially methylated positions (DMPs) were identified, affecting 744 genes. The genes were linked to biological processes, such as cellular metabolism, with significant pathway enrichment related to oxidative phosphorylation and chemical carcinogenesis. Additionally, the overweight group experienced significant reductions in methylation levels at eight lipogenesis-related genes. Protein EpiScore analysis revealed decreased levels of CCL11, VEGFA, and NTRK3 proteins at 14 weeks compared to baseline. Despite these significant molecular changes, there was no observable difference in DNAm age after the intervention. This study highlights how combined exercise can modify DNAm patterns in older women, particularly in lipogenesis-related genes, but suggests that further research is needed to understand the full implications for biological ageing. (AU) | |
| Processo FAPESP: | 20/08687-9 - Deficiência de selênio: identificação de um perfil de risco considerando fatores genéticos, clínicos e ambientais de pacientes com Obesidade no pré e pós-operatório da cirurgia bariátrica |
| Beneficiário: | Lígia Moriguchi Watanabe |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 14/16740-6 - Expressão de genes relacionados ao gasto energético e metabolismo de lipídios de indivíduos com obesidade grau III antes e após intervenções para perda de peso |
| Beneficiário: | Natália Yumi Noronha |
| Modalidade de apoio: | Bolsas no Brasil - Programa Capacitação - Treinamento Técnico |
| Processo FAPESP: | 18/24069-3 - Do biomonitoramento ao reconhecimento de assinaturas do exposoma humano visando antecipar riscos para uma saúde contínua |
| Beneficiário: | Fernando Barbosa Júnior |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 17/21361-2 - Screening global de fatores genéticos e epigenéticos associados com magnitude de resposta a diferentes treinamentos físicos em mulheres de 50 a 70 anos |
| Beneficiário: | Carlos Roberto Bueno Júnior |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |