| Texto completo | |
| Autor(es): Mostrar menos - |
Lima, Alex Ranieri Jeronimo
;
Santos, Hazerral de Oliveira
;
Pereira, James Siqueira
;
Leite, Anderson Brandao
;
do Nascimento, Jean Phellipe Marques
;
Souza, Juliana Vanessa Cavalcante
;
Lima, Marlon Breno Zampieri
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de Araujo, Mykaella Andrade
;
Giovanetti, Marta
;
Kallas, Esper Georges
;
Sampaio, Sandra Coccuzzo
;
Elias, Maria Carolina
;
Slavov, Svetoslav Nanev
Número total de Autores: 13
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Viruses-Basel; v. 17, n. 2, p. 8-pg., 2025-02-01. |
| Resumo | |
Enterovirus D68 (EV-D68) is a leading cause of acute respiratory disease outbreaks, especially among children. EV-D68 infections can rapidly progress to severe clinical complications and potentially fatal outcomes. In Brazil, no diagnostic or genomic surveillance of this virus is currently performed. Between July and September 2023, cases of acute EV-D68 infection were identified among pediatric patients in several municipalities within the State of Alagoas, Northeast Brazil. Infections were confirmed by RT-qPCR using nasopharyngeal samples, and the complete EV-D68 genomes were sequenced and analyzed through phylogenetic inference. EV-D68 RNA was identified in four children aged 1-9 years from four geographically distinct municipalities in Alagoas. All infections were associated with lower respiratory tract symptoms, including dyspnea and wheezing; however, no fatalities were reported. Complete genomic sequencing revealed that the samples belonged to genotype B, subgenotype B3. This is the first study to report complete genomic data on EV-D68 infections from Brazil and South America. Enhanced genomic surveillance and focused EV-D68 diagnosis are critical to better understanding and managing the regional and national dissemination of this virus. (AU) | |
| Processo FAPESP: | 21/11944-6 - Contínuo aprimoramento de vacinas: Centro para Vigilância Viral e Avaliação Sorológica (CeVIVAS) |
| Beneficiário: | Sandra Coccuzzo Sampaio Vessoni |
| Modalidade de apoio: | Auxílio à Pesquisa - Centros de Ciência para o Desenvolvimento |
| Processo FAPESP: | 17/23205-8 - Avaliação do impacto de vírus emergentes e re-emergentes em hemoterapia e transplante de células-tronco por meio de técnicas moleculares avançadas |
| Beneficiário: | Svetoslav Nanev Slavov |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 23/11919-7 - Identificação e caracterização de potenciais novas linhagens circulantes do vírus da dengue entre 2021 e 2026: contribuições para o monitoramento evolutivo |
| Beneficiário: | James Siqueira Pereira |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |