Microbial astaxanthin-encapsulated polymeric micelles from yeast Phaffia rhodozyma for personalized bioactive colored natural rubber latex bandages

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Mussagy, Cassamo U. ; Dias, Julia N. ; Caicedo-Paz, Angie V. ; Gini, Ana L. R. ; Scarim, Caue B. ; Tropea, Alessia ; La Tella, Roberta ; Mondello, Luigi ; Lopes-Filho, Paulo E. L. ; Tanaka, Jean L. ; Piazza, Rodolfo D. ; Marques, Rodrigo F. C. ; Santos, Lindomar S. ; Luiz, Marcela T. ; Chorilli, Marlus ; Santos-Ebinuma, Valeria C. ; Pessoa Jr, Adalberto ; Herculano, Rondinelli D.

• Tipo de documento: Artigo Científico
• Fonte: International Journal of Biological Macromolecules; v. 305, p. 17-pg., 2025-05-01.

Resumo

This study explores the development of bioactive, colored natural rubber latex (NRL) bandages by incorporating astaxanthin (AXT), a carotenoid with potent antioxidant and anti-inflammatory properties. AXT is produced by the yeast Phaffia rhodozyma under various light conditions to improve AXT biosynthesis and encapsulated in polymeric micelles to enhance its solubility and stability. The encapsulated AXT is then integrated into NRL bandages, imparting a orange-red hue and potentially therapeutic benefits. Physicochemical characterizations, including UV-Vis spectroscopy and FTIR, reveal interactions between AXT and the micelle components. The bandages exhibit improved hydrophilicity and maintain their thermal stability post-AXT incorporation. Antioxidant capacity assessments show that the NRL bandages retain a significant portion of AXT's antioxidant properties, which can aid in wound healing. The release profile of AXT from the bandages demonstrates an initial burst followed by sustained release, indicating effective delivery of the carotenoid. This innovative approach combines aesthetic appeal with biomedical advantages, offering a personalized solution for wound care applications. (AU)

• Processo FAPESP: 21/06686-8 - Processo biotecnológico visando o desenvolvimento de colorantes naturais microbianos para aplicação industrial: fase II
• Beneficiário: Valéria de Carvalho Santos Ebinuma
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOEN - Jovens Pesquisadores - Fase 2
• Processo FAPESP: 15/11759-3 - EMU concedido no processo 2014/17526-8: espectrômetro de ressonância paramagnética eletrônica (EPR) - Banda X
• Beneficiário: Rondinelli Donizetti Herculano
• Modalidade de apoio: Auxílio à Pesquisa - Programa Equipamentos Multiusuários
• Processo FAPESP: 23/17448-6 - "EMU: Aquisição de bioimpressora 3D, laser cutting e microscópio de fluorescência para implementação de facility (estrutura) de órgãos-em-um-chip e organóides"
• Beneficiário: Rondinelli Donizetti Herculano
• Modalidade de apoio: Auxílio à Pesquisa - Programa Infraestrutura - Pequeno Médio Porte