Anthelmintic Potential of Conjugated Long-Chain Fatty Acids Isolated from the Bioluminescent Mushroom Neonothopanus gardneri

Autor(es):Mostrar menos -

Oliveira, Maria D. A. ; Andrade, Teresinha de Jesus A. dos S. ; Joaquim Jr, S. C. ; Lima, Nerilson Marques ; Machado, Hugo G. ; Tabudravu, Jioji N. ; Pinto, Francisco das Chagas L. ; Fukui-Silva, Lucas ; Amaro, Monique C. ; de Moraes, Josue ; Silva, Dulce Helena S. ; Cito, Antonia Maria das Gracas L. ; Feitosa, Chistiane Mendes

• Tipo de documento: Artigo Científico
• Fonte: Journal of Natural Products; v. N/A, p. 7-pg., 2025-01-04.

Resumo

With praziquantel being the sole available drug for schistosomiasis, identifying novel anthelmintic agents is imperative. A chemical investigation of the fruiting body of the bioluminescent mushroom Neonothopanus gardneri Berk. resulted in the isolation of new conjugated long-chain fatty acids (8E,10E,12S,13S)-12,13-dihydroxy-7-oxo-octadeca-8,10-dienoic acid (1) and (7S,8S,9E,11E)-7,8-dihydroxy-13-oxo-octadeca-9,11-dienoic acid (2) and three previously described compounds, (7R,8R,9Z)-7,8-dihydroxyoctadec-9-enoic acid (3), (2E)-dec-2-ene-1,10-dioic acid (4), and a ketolactone marasmeno-1,15-dione (5). Their planar structures were elucidated based on 1D and 2D NMR and MS/MS spectroscopic analyses. Compound 3 displayed significant antiparasitic activity against Schistosoma mansoni ex vivo (EC50 < 10 mu M). No toxicity was observed in mammalian cells or Caenorhabditis elegans. (AU)

• Processo FAPESP: 23/08418-6 - Busca de metabólitos bioativos oriundos da biodiversidade brasileira como candidatos a fármacos para doenças causadas por helmintos
• Beneficiário: Josué de Moraes
• Modalidade de apoio: Auxílio à Pesquisa - Regular