| Texto completo | |
| Autor(es): Mostrar menos - |
Vicente, Thiago T.
;
Arsalani, Saeideh
;
Quiel, Mateus S.
;
Fernandes, Guilherme S. P.
;
da Silva, Keteryne R.
;
Fukada, Sandra Y.
;
Gualdi, Alexandre J.
;
Guidelli, Eder J.
;
Baffa, Oswaldo
;
Carneiro, Antonio A. O.
;
Ramos, Ana Paula
;
Pavan, Theo Z.
Número total de Autores: 12
|
| Tipo de documento: | Artigo Científico |
| Fonte: | PHARMACEUTICS; v. 16, n. 11, p. 22-pg., 2024-11-01. |
| Resumo | |
Background/Objectives: Magnetic nanoparticles (MNPs) have gained attention in theranostics for their ability to combine diagnostic imaging and therapeutic capabilities in a single platform, enhancing targeted treatment and monitoring. Surface coatings are essential for stabilizing MNPs, improving biocompatibility, and preventing oxidation that could compromise their functionality. Natural rubber latex (NRL) offers a promising coating alternative due to its biocompatibility and stability-enhancing properties. While NRL-coated MNPs have shown potential in applications such as magnetic resonance imaging, their effectiveness in theranostics, particularly magnetic hyperthermia (MH) and photoacoustic imaging (PAI), remains underexplored. Methods: In this study, iron oxide nanoparticles were synthesized via coprecipitation, using NRL as the coating agent. The samples were labeled by NRL amount used during synthesis: NRL-100 for 100 mu L and NRL-400 for 400 mu L. Results: Characterization results showed that NRL-100 and NRL-400 samples exhibited improved stability with zeta potentials of -27 mV and -30 mV, respectively and higher saturation magnetization values of 79 emu/g and 88 emu/g of Fe3O4. Building on these findings, we evaluated the performance of these nanoparticles in biomedical applications, including magnetomotive ultrasound (MMUS), PAI, and MH. NRL-100 and NRL-400 samples showed greater displacements and higher contrast in MMUS than uncoated samples (5, 8, and 9 mu m) at 0.5 wt%. In addition, NRL-coated samples demonstrated an improved signal-to-noise ratio (SNR) in PAI. SNR values were 24.72 (0.51), 31.44 (0.44), and 33.81 (0.46) dB for the phantoms containing uncoated MNPs, NRL-100, and NRL-400, respectively. Calorimetric measurements for MH confirmed the potential of NRL-coated MNPs as efficient heat-generating agents, showing values of 43 and 40 W/g for NRL-100 and NRL-400, respectively. Conclusions: Overall, NRL-coated MNPs showed great promise as contrast agents in MMUS and PAI imaging, as well as in MH applications. (AU) | |
| Processo FAPESP: | 18/16939-8 - Desenvolvimento e implementação de novas técnicas acústicas, magnéticas e ópticas para aplicações diagnósticas e terapêuticas |
| Beneficiário: | Antonio Adilton Oliveira Carneiro |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 21/06728-2 - Imagens fotoacústicas e ultrassônicas em aplicações teranósticas |
| Beneficiário: | Theo Zeferino Pavan |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores - Fase 2 |
| Processo FAPESP: | 13/18854-6 - Imagens fotoacústicas e ultrassônicas para caracterização de tecidos viscoelásticos |
| Beneficiário: | Theo Zeferino Pavan |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 17/14482-8 - Redução de artefatos para geração de imagem híbrida ultrassom/fotoacústica |
| Beneficiário: | Guilherme Santos Pilotto Fernandes |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |
| Processo FAPESP: | 13/07699-0 - Centro de Pesquisa, Inovação e Difusão em Neuromatemática - NeuroMat |
| Beneficiário: | Oswaldo Baffa Filho |
| Modalidade de apoio: | Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs |