| Texto completo | |
| Autor(es): |
Assaf, Luciene
;
Makyiama, Edson Naoto
;
Almeida, Beatriz
;
de Almeida Junior, Jeremias Martins
;
Goncalves, Carlos Eduardo da Silva
;
de Freitas, Sumara
;
Amon, Rosana Lopes Rodrigues
;
Neves, Bruna Roberta Oliveira
;
Rogero, Marcelo Macedo
;
Fock, Ricardo Ambrosio
Número total de Autores: 10
|
| Tipo de documento: | Artigo Científico |
| Fonte: | NATURAL PRODUCT RESEARCH; v. N/A, p. 6-pg., 2025-01-31. |
| Resumo | |
Anthocyanins, water-soluble flavonoids found in fruits and vegetables, exhibit diverse biological activities, with cyanidin being the most common pigment. While cyanidin's chemo preventive and antioxidant activity is well-studied, its impact on inflammatory profile and migration capacity of leukemic cells are less understood. This study evaluates the effects of Cyanidin-3-glucoside (C3G) on the inflammatory mechanisms influencing leukemic cell migration. Results show that C3G doses up to 50 mu M do not affect cell metabolism, viability, or cell cycle phases. C3G significantly reduces TNF-alpha, IL-8, CCL2 production, and the p-NF kappa B/NF kappa B ratio in LPS (Lipopolysaccharide)-challenged cells. It also diminishes migration rates in response to LPS or fMLP (N-formyl-methionyl-leucyl-phenylalanine) stimulation and reduces Rho-GTP expression. Thus, C3G modifies the inflammatory and migration properties of leukemic cells, highlighting the potential of anthocyanins as a complementary therapy and an avenue for further therapeutic intervention. (AU) | |
| Processo FAPESP: | 21/08658-1 - Influência da desnutrição proteica em idosos sobre aspectos imunomodulatórios das células estromais mesenquimais medulares e sua ação na regulação da hematopoese |
| Beneficiário: | Ricardo Ambrósio Fock |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |