Evaluation of myelin content in the spinal cord of patients with multiple sclerosis: A positron emission tomography study

Autor(es)

de Lucena, Leticia Zorante ; Campanholo, Kenia Repiso ; Pereira, Samira Luiza Apostolos ; Tavora, Daniel Gurgel Fernandes ; Callegaro, Dagoberto ; Buchpiguel, Carlos Alberto ; Pitombeira, Milena Sales ; Faria, Daniele de Paula

• Tipo de documento: Artigo Científico
• Fonte: MULTIPLE SCLEROSIS AND RELATED DISORDERS; v. 93, p. 8-pg., 2024-12-28.

Resumo

Background: Multiple sclerosis (MS) is divided into Relapsing-Remitting (RRMS) and Progressive (PMS) phenotypes, both associated with spinal cord (SC) damage. MS-related disability and SC atrophy are not yet fully understood and can differ across phenotypes. A combined approach using Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) could provide a broader understanding of myelin changes in the cervical SC (CSC) in different MS phenotypes and the associations with disability. Objectives: To evaluate CSC myelin content using a PET-MRI with [11C]PIB and its association with disability in PMS and RRMS compared to healthy volunteers (HV). Methods: [11C]PIB PET images and T1-MRI of 49 patients with MS and 19 HV were evaluated at C1-C2, C3, and C4 vertebrae levels. [11C]PIB uptake and volume were compared between groups. Results: [11C]PIB uptake was significantly lower at C1-C4, C1-C2, and C3 segments when comparing PMS to RRMS and HV. [11C]PIB uptake inversely correlated with overall disability in all CSC segments in all patients with MS, and in the RRMS phenotype separately. Conclusions: Our findings suggest an association between [11C]PIB CSC uptake and overall disability score measured by EDSS. MRI and PET can be used as complementary methods for studying MS. (AU)

• Processo FAPESP: 18/15167-1 - Neuroimagem translacional na deficiência intelectual: avaliação de alterações moleculares associadas ao envelhecimento na Síndrome de Down
• Beneficiário: Daniele de Paula Faria
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 21/00293-4 - Avaliação de neuroinflamação e conteúdo de mielina utilizando imagens de PET/RM de medula cervical de pacientes com Esclerose Múltipla e voluntários saudáveis
• Beneficiário: Leticia Zorante de Lucena
• Modalidade de apoio: Bolsas no Brasil - Mestrado