| Texto completo | |
| Autor(es): |
de Castro, Tatiany Aparecida
;
Hassumi, Jaqueline Suemi
;
Juliao, Gabriela Morais
;
Dutra, Marina Correa
;
da Silva, Ana Claudia Ervolino
;
Monteiro, Naara Gabriela
;
Batista, Fabio Roberto de Souza
;
Mulinari-Santos, Gabriel
;
Lisboa-Filho, Paulo Noronha
;
Okamoto, Roberta
Número total de Autores: 10
|
| Tipo de documento: | Artigo Científico |
| Fonte: | MATERIALS; v. 18, n. 3, p. 17-pg., 2025-02-01. |
| Resumo | |
Estrogen deficiency, coupled with a cafeteria diet (CD), can impair peri-implant bone repair, posing a significant challenge to implant success in affected individuals. Thus, it is crucial to explore strategies for implant functionalization and systemic treatments that could alleviate these bone alterations. This study aimed to assess peri-implant bone repair in ovariectomized (OVX) rats subjected to a CD, with a focus on implants functionalized with genistein (GEN), compared to conventional implants (CONV), and the effects of systemic treatment with risedronate sodium (RIS). In total, thirty-six female rats were assigned to three groups: rats with estrogen (SHAM), rats with estrogen deficiency and CD (OVX-CD), rats with estrogen deficiency, CD, and systemic RIS treatment (OVX-CD-RIS). All rats underwent bilateral extraction of the first upper molars followed by implant installation. Each group was further subdivided based on implant type: conventional implants (CONV) or GEN-functionalized implants, resulting in six subgroups (n = 6). The study employed several analyses, including reverse torque testing, microcomputed tomography (Micro-CT), epifluorescence microscopy, and molecular assays. The main result demonstrated that the OVX-CD-RIS/GEN subgroup exhibited significantly higher reverse torque values, indicating stronger implant stability. Micro-CT scans revealed a greater bone volume in the OVX-CD-RIS/GEN subgroup compared to other subgroups. Epifluorescence microscopy also demonstrated an increased mineral apposition rate in both the OVX-CD/GEN and OVX-CD-RIS/GEN subgroups. Molecular analysis indicated elevated expression levels of osteocalcin, alkaline phosphatase, and vascular endothelial growth factor in the OVX-CD-RIS/GEN subgroup. In conclusion, the combined treatment of systemic RIS and GEN-functionalized implants significantly enhanced peri-implant bone repair, offering a promising strategy to improve implant outcomes in postmenopausal women with metabolic syndrome. (AU) | |
| Processo FAPESP: | 19/13954-9 - Avaliação do efeito sinérgico entre risedronato sistêmico e genisteína local sobre o reparo peri-implantar em ratas com deficiência de estrógeno e síndrome metabólica |
| Beneficiário: | Jaqueline Suemi Hassumi |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |
| Processo FAPESP: | 18/03114-0 - Associação de terapias medicamentosas sistêmica e locais durante o processo de reparo periimplantar de ratas ovariectomizadas portadoras de síndrome metabólica. |
| Beneficiário: | Roberta Okamoto |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 21/11045-1 - Impacto da associação de bifosfonato sistêmico e genisteína local na biomineralização durante o processo de reparo periimplantar em ratas com deficiência de estrógeno e portadoras de síndrome metabólica. |
| Beneficiário: | Tatiany Aparecida de Castro |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |