| Texto completo | |
| Autor(es): Mostrar menos - |
Martignago, Cintia Cristina Santi
;
Barbosa, Camila de Souza
;
Motta, Homero Garcia
;
Soares-Silva, Beatriz
;
Peres, Erica Paloma Maso Lopes
;
Silva, Lais Caroline
;
Bonifacio, Mirian
;
Sousa, Karolyne dos Santos Jorge
;
Alqualo, Amanda Sardeli
;
Parisi, Julia
;
Jordan, Olivier
;
Renno, Ana Claudia Muniz
;
Aguiar, Anna Caroline Campos
;
Patrulea, Viorica
Número total de Autores: 14
|
| Tipo de documento: | Artigo Científico |
| Fonte: | MARINE DRUGS; v. 23, n. 1, p. 17-pg., 2025-01-01. |
| Resumo | |
The rise in multidrug-resistant (MDR) bacteria has prompted extensive research into antibacterial compounds, as these resistant strains compromise current treatments. This resistance leads to prolonged hospitalization, increased mortality rates, and higher healthcare costs. To address this challenge, the pharmaceutical industry is increasingly exploring natural products, particularly those of marine origin, as promising candidates for antimicrobial drugs. Marine sponges, in particular, are of interest because of their production of secondary metabolites (SM), which serve as chemical defenses against predators and pathogens. These metabolites exhibit a wide range of therapeutic properties, including antibacterial activity. This systematic review examines recent advancements in identifying new sponge-derived compounds with antimicrobial activity, specifically targeting Pseudomonas aeruginosa, a prevalent Gram-negative pathogen with the highest incidence rates in clinical settings. The selection criteria focused on antimicrobial compounds with reported Minimum Inhibitory Concentration (MIC) values. The identified SM include alkaloids, sesterterpenoids, nitrogenous diterpene, and bromotyrosine-derived derivatives. The structural features of the active compounds selected in this review may provide a foundational framework for developing new, highly bioactive antimicrobial agents. (AU) | |
| Processo FAPESP: | 23/13928-3 - DESENVOLVIMENTO DE MICELAS mPEG-PLA PARA A ENTREGA DO COMPOSTO BIOATIVO EXTRAÍDO DA ESPONJA MARINHA DYSIDEA ROBUSTA CONTRA BACTÉRIAS RESISTENTES A MÚLTIPLAS DROGAS |
| Beneficiário: | Cintia Cristina Santi Martignago |
| Modalidade de apoio: | Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado |
| Processo FAPESP: | 19/19708-0 - Identificação de novos compostos antimaláricos: uma estratégia multidisciplinar visando a busca por classes ativas contra novos alvos moleculares e diferentes estágios de vida do Plasmodium spp |
| Beneficiário: | Anna Caroline Campos Aguiar |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 21/02974-9 - Rede interdisciplinar para o desenvolvimento biotecnológico de biomateriais de origem marinha para uso na saúde humana: acometimentos patológicos do sistema osteoarticular |
| Beneficiário: | Cintia Cristina Santi Martignago |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |