Maxillary Mesenchymal Chondrosarcoma Affecting A Pediatric Patient: Case Report Showing Long-Term Follow-Up and Detailed Literature Review

Autor(es)

Silveira, Heitor Albergoni ; Silva, Andreia Aparecida ; Dias, Rafael Rodrigues ; Martins, Karina Helen ; da Silva, Anderson Tangerino Ferreira ; Cardoso, Camila Lopes ; Leon, Jorge Esquiche

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF MAXILLOFACIAL & ORAL SURGERY; v. N/A, p. 5-pg., 2025-02-09.

Resumo

IntroductionMesenchymal chondrosarcoma (MC) is a rare neoplasm representing about 3% of all chondrosarcomas and 0.1% of all head and neck cancers. To date, about 94 MCs affecting the jaws have been reported. Of them, 28 cases affected pediatric patients, which appear to have a favorable prognosis. Herein, we report an additional maxillary MC.Case Description: A 9-year-old boy was referred presenting an asymptomatic and expansive mass in the left maxilla with six months of evolution. CT scans revealed an expansile osteolytic lesion with granular irregularly shaped calcifications invading the nasal and orbital cavity and infiltrating the maxillary sinus with destruction of its posterolateral wall. Microscopic examination revealed dense sheets of small to medium-sized, poorly differentiated round cells arranged in hemangioperycitoma-like vascular pattern surrounded by nodules of mature cartilage. Immunopositivity for vimentin, S100, and CD99 were observed.Diagnosis and Treatment: The final diagnosis was MC. After neoadjuvant chemotherapy, partial maxillectomy was performed. Currently, with 13 years of follow-up, the patient remains well, with no evidence of recurrence or metastasis.IntroductionMesenchymal chondrosarcoma (MC) is a rare neoplasm representing about 3% of all chondrosarcomas and 0.1% of all head and neck cancers. To date, about 94 MCs affecting the jaws have been reported. Of them, 28 cases affected pediatric patients, which appear to have a favorable prognosis. Herein, we report an additional maxillary MC.Case Description: A 9-year-old boy was referred presenting an asymptomatic and expansive mass in the left maxilla with six months of evolution. CT scans revealed an expansile osteolytic lesion with granular irregularly shaped calcifications invading the nasal and orbital cavity and infiltrating the maxillary sinus with destruction of its posterolateral wall. Microscopic examination revealed dense sheets of small to medium-sized, poorly differentiated round cells arranged in hemangioperycitoma-like vascular pattern surrounded by nodules of mature cartilage. Immunopositivity for vimentin, S100, and CD99 were observed.Diagnosis and Treatment: The final diagnosis was MC. After neoadjuvant chemotherapy, partial maxillectomy was performed. Currently, with 13 years of follow-up, the patient remains well, with no evidence of recurrence or metastasis.IntroductionMesenchymal chondrosarcoma (MC) is a rare neoplasm representing about 3% of all chondrosarcomas and 0.1% of all head and neck cancers. To date, about 94 MCs affecting the jaws have been reported. Of them, 28 cases affected pediatric patients, which appear to have a favorable prognosis. Herein, we report an additional maxillary MC.Case Description: A 9-year-old boy was referred presenting an asymptomatic and expansive mass in the left maxilla with six months of evolution. CT scans revealed an expansile osteolytic lesion with granular irregularly shaped calcifications invading the nasal and orbital cavity and infiltrating the maxillary sinus with destruction of its posterolateral wall. Microscopic examination revealed dense sheets of small to medium-sized, poorly differentiated round cells arranged in hemangioperycitoma-like vascular pattern surrounded by nodules of mature cartilage. Immunopositivity for vimentin, S100, and CD99 were observed.Diagnosis and Treatment: The final diagnosis was MC. After neoadjuvant chemotherapy, partial maxillectomy was performed. Currently, with 13 years of follow-up, the patient remains well, with no evidence of recurrence or metastasis. ConclusionThe current case emphasizes that MC affecting pediatric patients with maxillary location appears to be associated with an indolent course and favorable prognosis. (AU)

• Processo FAPESP: 18/12734-2 - Caracterização imunoistoquímica comparativa de subgrupos de células dendríticas e oncogênese viral no carcinoma espinocelular oral e orofaríngeo
• Beneficiário: Heitor Albergoni da Silveira
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 16/11419-0 - Correlação clinicopatológica do grau de diferenciação, expressão de tetraspaninas, agentes virais e proliferação celular em uma ampla série de carcinomas espinocelulares da região de cabeça e pescoço.
• Beneficiário: Jorge Esquiche León
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 22/12760-9 - Correlação clinicopatológica do sistema imune, diferenciação celular, angiogênese, metabolismo lipídico e HPV transcricionalmente ativo em uma ampla série de carcinomas espinocelulares da região de cabeça e pescoço
• Beneficiário: Jorge Esquiche León
• Modalidade de apoio: Auxílio à Pesquisa - Regular