Gut colonization of semi-aquatic turtles inhabiting the Brazilian Amazon by international clones of CTX-M-8-producing Escherichia coli

Autor(es)

da Silva, Meire Maria ; Sellera, Fabio Parra ; Furlane, Joao Pedro Rueda ; Aravena-Ramirez, Valentina ; Fuentes-Castillo, Danny ; Fuga, Bruna ; Froesi, Alexandre Jose dos Santos ; de Sousai, Alana Lislea ; Garino Junior, Felicio ; Lincopan, Nilton

• Tipo de documento: Artigo Científico
• Fonte: Veterinary Microbiology; v. 301, p. 8-pg., 2024-12-23.

Resumo

Extended-spectrum (3-lactamase (ESBL)-producing Escherichia coli poses a significant threat to public health due to its ability to confer resistance to broad-spectrum antimicrobials, especially third-generation cephalosporins. Herein, we report gut colonization by international clones of CTX-M-8-producing E. coli in scorpion mud turtles (Kinosternon scorpioides) from a captive breeding program in the Brazilian Amazon. The E. coli strains exhibited multidrug resistance to clinically relevant antimicrobials, and genomic analyses revealed broad resistomes to antimicrobials, heavy metals, pesticides, and disinfectants. Detecting these medically important bacteria in captive wildlife underscores the potential risks associated with reintroduction programs, as ESBL-producing bacteria may spill over into the natural ecosystem and threaten wildlife. Our findings highlight the need for enhanced surveillance and control measures in wildlife conservation programs to mitigate the risks of antimicrobial resistance transmission between captive and wild populations. (AU)

• Processo FAPESP: 20/08224-9 - One Health Brazilian Resistance (OneBR): base genômica integrada para vigilância, diagnóstico e tratamento da resistência aos antimicrobianos na interface humana-ambiente-animal, no Brasil
• Beneficiário: Nilton Erbet Lincopan Huenuman
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 23/16216-4 - Investigação genômica de probióticos/bacteriocinas para o tratamento de patógenos resistentes a antimicrobianos
• Beneficiário: João Pedro Rueda Furlan
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado