Nanomedicine Innovations for Lung Cancer Diagnosis and Therapy

Autor(es)

Cardoso, Valeria Maria de Oliveira ; Bistaffa, Maria Julia ; Sterman, Raquel Gonzalez ; Lima, Lorena Leticia Peixoto de ; Toldo, Gustavo Silveira ; Cancino-Bernardi, Juliana ; Zucolotto, Valtencir

• Tipo de documento: Artigo Científico
• Fonte: ACS APPLIED MATERIALS & INTERFACES; v. N/A, p. 24-pg., 2024-12-31.

Resumo

Lung cancer remains a challenge within the realm of oncology. Characterized by late-stage diagnosis and resistance to conventional treatments, the currently available therapeutic strategies encompass surgery, radiotherapy, chemotherapy, immunotherapy, and biological therapy; however, overall patient survival remains suboptimal. Nanotechnology has ushered in a new era by offering innovative nanomaterials with the potential to precisely target cancer cells while sparing healthy tissues. It holds the potential to reshape the landscape of cancer management, offering hope for patients and clinicians. The assessment of these nanotechnologies follows a rigorous evaluation process similar to that applied to chemical drugs, which includes considerations of their pharmacokinetics, pharmacodynamics, toxicology, and clinical effectiveness. However, because of the characteristics of nanoparticles, standard toxicological tests require modifications to accommodate their unique characteristics. Effective therapeutic strategies demand a profound understanding of the disease and consideration of clinical outcomes, physicochemical attributes of nanomaterials, nanobiointeractions, nanotoxicity, and regulatory compliance to ensure patient safety. This review explores the promise of nanomedicine in lung cancer treatment by capitalizing on its unique physicochemical properties. We address the multifaceted challenges of lung cancer and its tumor microenvironment and provide an overview of recent developments in nanoplatforms for early diagnosis and treatment that can enhance patient outcomes and overall quality of life. (AU)

• Processo FAPESP: 23/01689-4 - Investigação espectroeletroquímica de sensores e biossensores baseados em nanopartículas plasmônicas fotoativadas
• Beneficiário: Juliana Cancino Bernardi
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 23/14785-1 - Estudo da conversão eletroquímica aprimorada por plasmons em sensores via microscopia eletroquímica de varredura e microscopia de força atômica
• Beneficiário: Juliana Cancino Bernardi
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 20/00124-5 - Nanomateriais funcionalizados para aplicação em terapias contra o câncer
• Beneficiário: Valtencir Zucolotto
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 22/01434-3 - Nanopartículas biomiméticas revestidas com membranas celulares como estratégia inovadora na terapia do câncer de pulmão
• Beneficiário: Maria Julia Bistaffa
• Modalidade de apoio: Bolsas no Brasil - Doutorado