Coordination Compounds as Antivirals against Neglected Tropical Diseases

Autor(es)

Rezende, Wallace S. ; Neto, Antonio Marcal ; Corbi, Juliano J. ; Corbi, Pedro P. ; de Paiva, Raphael E. F. ; Bergamini, Fernando R. G.

• Tipo de documento: Artigo Científico
• Fonte: CHEMMEDCHEM; v. N/A, p. 18-pg., 2024-12-09.

Resumo

Neglected tropical viral diseases are a burden to social and economic welfare being responsible for higher pathogen-related mortality rates and chronic debilitating patient conditions. Climatic changes have widened up the infectibility ratio of such diseases, with autochthonous transmission in formerly temperate-to-cold environments. The slow-paced development of potential vaccines followed by the inexistence of antiviral drugs for such diseases considerably worsens the situation. Coordination compounds are a class of molecules that have been extensively explored as antiviral drugs for viruses such as poliovirus, HIV and, more recently, SARS-CoV-2, figuring as potential molecules to be explored and capitalized as antivirals against neglected viral strains. In this review the current efforts from the inorganic medicinal chemistry to address viral neglected tropical diseases, with emphasis to coordination compounds, is presented. Since many of neglected viruses are also arthropod-borne viruses, relying on a vector for transmission, coordination entities able to mitigate vectors are also presented as a parallel strategy to prevent and control such diseases. (AU)

• Processo FAPESP: 21/10265-8 - Centro de Inovação Teranóstica em Câncer (CancerThera)
• Beneficiário: Carmino Antonio de Souza
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 20/09912-6 - Ativa-ETE: avaliação de tecnologias inovadoras voltadas à remoção de nitrogênio e micropoluentes em ETE
• Beneficiário: José Alberto Domingues Rodrigues
• Modalidade de apoio: Auxílio à Pesquisa - Parceria para Inovação Tecnológica - PITE