Interaction of Phenanthroline-Containing Copper Complexes with Model Phospholipid Membranes

Autor(es)

Freddi, Priscilla ; Alvarez, Natalia ; Facchin, Gianella ; Costa-Filho, Antonio J.

• Tipo de documento: Artigo Científico
• Fonte: INORGANICS; v. 12, n. 12, p. 12-pg., 2024-12-01.

Resumo

Medicinal Inorganic Chemistry has provided oncology with metallodrugs for cancer treatment, including several promising candidate drugs. In particular, copper(II) coordination compounds with phenanthroline stand out as potential anticancer agents. In this work, we used Differential Scanning Calorimetry and Electron Spin Resonance to investigate the interaction of the copper phenanthroline complexes [Cu(phen)]2+ and [Cu(L-dipeptide)(phenanthroline) (L-dipeptide: L-Ala-Gly and L-Ala-Phe)) with model lipid membranes (1,2-dipalmitoyl-sn-glycero-3-phosphocholine, DPPC, and 1,2-dipalmitoyl-sn-glycero-3-phospho-(1 '-rac-glycerol) sodium salt, DPPG). Our results showed that the complexes interact with the membrane models, fluidizing them. The [Cu(phen)]2+ presented a different localization than the free ligand phen. The dipeptide modulated the localization of the complex in the membrane and the modifications induced in the physicochemical properties of the lipid vesicles. A stronger interaction with DPPG anionic membranes was observed, which mimic membranes with negatively charged surfaces, as found on several tumor cells. (AU)

• Processo FAPESP: 23/04532-9 - A peculiar biofísica da secreção não convencional de proteínas: novos e velhos olhares para novos e velhos problemas
• Beneficiário: Antonio José da Costa Filho
• Modalidade de apoio: Auxílio à Pesquisa - Temático