| Texto completo | |
| Autor(es): |
Metz, German Ernesto
;
Azcurra, Miriam Beatriz
;
de Souza, Guilherme Sastre
;
Brasil, Maria Carolina Oliveira de Arruda
;
Cilli, Eduardo Maffud
;
Lorenzon, Esteban Nicolas
Número total de Autores: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS; v. 31, n. 3, p. 5-pg., 2025-02-17. |
| Resumo | |
Equine viral arteritis is an economically important contagious disease caused by equine arteritis virus (EAV). Our objective was to evaluate the antiviral activity of indolicidin and K-indolicidin peptides against EAV. We found that indolicidin, but not K-indolicidin, completely inhibits EAV. Furthermore, indolicidin did not affect sperm quality parameters, the primary source of EAV transmission. This is the first report showing the potential of indolicidin as a candidate for use as a therapeutic agent against EAV and an additive in equine semen extenders. (AU) | |
| Processo FAPESP: | 22/05411-8 - Desenvolvimento de bioconjugados peptídeos/guanidinas com atividade anti-Leishmania |
| Beneficiário: | Eduardo Maffud Cilli |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |