LncRNAs in melanoma phenotypic plasticity: emerging targets for promising therapies

Autor(es)

Beatriz Cristina Biz, Tonin ; Carolina de Sousa, Castro-Silva ; Frank John, Slack ; Miriam Galvonas, Jasiulionis

• Tipo de documento: Artigo Científico
• Fonte: RNA BIOLOGY; v. 21, n. 1, p. 13-pg., 2024-12-31.

Resumo

Long non-coding RNAs (lncRNAs) have received growing attention due to their diverse regulatory roles in cancer, including in melanoma, an aggressive type of skin cancer. The plasticity and phenotypic adaptability of melanoma cells are crucial factors contributing to therapeutic resistance. The identification of molecules playing key roles in melanoma cell plasticity could unravel novel and more effective therapeutic targets. This review presents current concepts of melanoma cell plasticity, illustrating its fluidity and dismissing the outdated notion of epithelial-mesenchymal-like transition as a simplistic binary process. Emphasis is placed on the pivotal role of lncRNAs in orchestrating cell plasticity, employing various mechanisms recently elucidated and unveiling their potential as promising targets for novel therapeutic strategies. Insights into the molecular mechanisms coordinated by lncRNAs in melanoma pave the way for the development of RNA-based therapies, holding great promise for enhancing treatment outcomes and offering a glimpse into a more effective approach to melanoma treatment. (AU)

• Processo FAPESP: 21/06214-9 - Análise do papel de lncRNAs com valor prognóstico na progressão do Melanoma
• Beneficiário: Beatriz Cristina Biz Tonin
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 22/00322-7 - Identificação e caracterização de ncRNAs com papel na plasticidade fenotípica do Melanoma
• Beneficiário: Miriam Galvonas Jasiulionis
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 18/20775-0 - RNAs não codificantes envolvidos com a gênese e a progressão do melanoma
• Beneficiário: Miriam Galvonas Jasiulionis
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 21/06985-5 - Busca por novas estratégias terapêuticas pela inibição de enzimas modificadoras de histonas em características malignas de células de melanoma de diferentes fenótipos
• Beneficiário: Carolina de Sousa Castro Silva
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica