Determination of the Attenuation Coefficient by OCT in Cutaneous Melanoma After the Application of Optical Clearing Agents

Autor(es)

Martinelli, Leticia Palombo ; Moriyama, Lilian Tan ; Kurachi, Cristina

• Tipo de documento: Artigo Científico
• Fonte: 2024 SBFOTON INTERNATIONAL OPTICS AND PHOTONICS CONFERENCE, SBFOTON IOPC 2024; v. N/A, p. 3-pg., 2024-01-01.

Resumo

Melanoma is the most aggressive skin cancer, originating from melanin-producing melanocytes, it is highly metastatic and challenging to treat. Light-based therapies such as photodynamic and photothermal treatments are promising but limited by melanin's light-absorbing properties. Optical clearing agents (OCAs), which promotes refractive index matching, can enhance these therapies by improving light penetration. In the present study, we analyzed the effect of OCAs in a cutaneous melanoma model by obtaining the attenuation coefficient using optical coherence tomography. A reduction of up to 43% in the attenuation coefficient was observed in melanoma after OCA application, confirming their effectiveness in decreasing light attenuation, allowing deeper light penetration into the tumor. (AU)

• Processo FAPESP: 13/07276-1 - CEPOF - Centro de Pesquisa em Óptica e Fotônica
• Beneficiário: Vanderlei Salvador Bagnato
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 14/50857-8 - INCT 2014 - de Óptica Básica e Aplicada às Ciências da Vida
• Beneficiário: Vanderlei Salvador Bagnato
• Modalidade de apoio: Auxílio à Pesquisa - Temático