| Texto completo | |
| Autor(es): |
Cardinali, Camila A. E. F.
;
Martins, Yandara A.
;
Moraes, Ruan C. M.
;
Costa, Andressa P.
;
Torrao, Andrea S.
Número total de Autores: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Molecular Neurobiology; v. N/A, p. 23-pg., 2025-03-04. |
| Resumo | |
Alzheimer's disease (AD) is the most prevalent cause of dementia, characterized by progressive memory loss and cognitive decline. Recent evidence indicates that inflammation plays a central role in AD pathogenesis, with elevated inflammatory markers and risk genes linked to innate immune functions. Glial cell dysfunction, particularly in astrocytes and microglia, is crucial to the neuroinflammatory process, contributing to oxidative stress, synaptic dysfunction, neuronal death, and impaired neurogenesis. This study aimed to investigate the therapeutic effects of benfotiamine (BFT), a vitamin B1 analogue, on microglial morphology, inflammation, and oxidative stress parameters in a sporadic Alzheimer-like disease model induced by intracerebroventricular injection of streptozotocin (STZ). Supplementation with 150 mg/kg of BFT for 7 days significantly reduced inflammation in the hippocampus and provided protection against oxidative damage in the entorhinal cortex by activating the Nrf-2 pathway and enhancing the expression of antioxidant enzymes such as SOD1 and CAT. These findings suggest that BFT exerts neuroprotective effects in AD, particularly impacting glial cell function and redox homeostasis. (AU) | |
| Processo FAPESP: | 21/12620-0 - Composição de membrana celular e estresse oxidativo no sistema nervoso durante o envelhecimento e a neurodegeneração |
| Beneficiário: | Andréa da Silva Torrão |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 17/10801-1 - Benfotiamina e hormônio tireoideano: influência sobre o metabolismo energético neuronal e a progressão da neurodegeneração em um modelo experimental semelhante à Doença de Alzheimer |
| Beneficiário: | Andréa da Silva Torrão |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |