Autor(es)

Dammak, Ilyes ; Cherif, Slim ; Sobral, Paulo Jose do Amaral

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY; v. N/A, p. 15-pg., 2025-02-22.

Resumo

Nanoemulsions (NEs) have emerged as versatile delivery systems for bioactive compounds, with growing interest in developing "label-friendly" formulations. This study examines the physicochemical stability of NEs coencapsulating beta-carotene and (-)-alpha-bisabolol, employing natural emulsifiers soy lecithin (SL) and sodium caseinate (NaCas). Utilizing a microfluidization technique, the NEs were formulated with 0.1% w/v beta-carotene and 0.05% v/v (-)-alpha-bisabolol. Our findings reveal that SL effectively reduced oil droplet coalescence at a concentration of approximately 1% w/w, achieving a mean droplet size (d3,2) of about 170 nm. Conversely, NaCas, at a higher concentration of 2% w/w, showed enhanced effectiveness in preventing droplet aggregation, especially under varying environmental stressors such as thermal exposure (40 and 60 degrees C) and pH range (3-9). The physical stability of the NEs was rigorously evaluated using a LUMiSizer (R), providing essential insights into creaming rates and emulsion behaviors. This comprehensive analysis quantitatively delineated the creaming behaviors and stability characteristics of NEs stabilized with SL and NaCas. Additionally, SL-stabilized NEs displayed superior antioxidant activity, with an IC50 value of 12.50 mg/mL in the DPPH assay. These findings underscore the potential of natural emulsifiers in enhancing the stability of emulsion-based products and natural emulsifier selection in optimizing NE formulations for bioactive compound delivery. (AU)

• Processo FAPESP: 15/02879-5 - Development of nanocomposites with active principles added as nanoemulsion
• Beneficiário: Ilyes Dammak
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado