| Texto completo | |
| Autor(es): |
de Melo, Karla Pacheco
;
de Souza, Giovana Salla Siqueira
;
Ibrahim, Emad
;
Lynne, Charles M.
;
Brackett, Nancy L.
;
Bertolla, Ricardo Pimenta
;
Camargo, Mariana
Número total de Autores: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF SPINAL CORD MEDICINE; v. N/A, p. 7-pg., 2025-04-03. |
| Resumo | |
Objective To evaluate seminal plasma levels of Biglycan, Cystatin-S, beta-2 microglobulin and inflammasome proteins and to investigate their role in seminal toxicity in men with spinal cord injury (SCI). Study design cross-sectional study. Setting Miami Project to Cure Paralysis - University of Miami / Miller School of Medicine and Federal University of Sao Paulo. Participants Eight men with spinal cord injury and eight men without spinal cord injury (controls). Intervention: none Outcome measures: semen analysis as per WHO 2010 guidelines; seminal plasma ELISA for IL-1 beta, IL-18 and caspase-1; and Western blotting for Biglycan, beta-2microglobulin and Cystatin-S proteins. Results Proteins from the inflammasome complex are elevated in men with SCI, as previously described. In addition, beta-2-microgobulin, Cystatin-S and two different isoforms of Byglican are elevated in men with SCI. Conclusion: a different pathway to activate the inflammasome complex is present in men with spinal cord injury. This pathway can be a potential target for new interventions in the future. (AU) | |
| Processo FAPESP: | 18/25907-2 - Análise da mitofagia espermática após fertilização in vitro |
| Beneficiário: | Karla Pacheco de Melo |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |
| Processo FAPESP: | 17/14346-7 - Lesão medular e infertilidade masculina: efeito do tratamento com probenecida sobre a toxicidade seminal de origem prostática. |
| Beneficiário: | Mariana Camargo |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |