Haplotypes in the Interleukin 8 Gene and Their Association with Chronic Periodontitis Susceptibility

Autor(es)

Scarel-Caminaga, Raquel M. ^[1] ; Kim, Yeon J. ^[2] ; Viana, Aline C. ^[2] ; Curtis, Karen M. C. ^[1] ; Corbi, Samia C. T. ^[2] ; Sogumo, Patricia M. ^[1] ; Orrico, Silvana R. P. ^[2] ; Cirelli, Joni A. ^[2]

Afiliação do(s) autor(es)

^[1] UNESP Sao Paulo State Univ, Sch Dent Araraquara, Dept Morphol, BR-14801903 Araraquara, SP - Brazil

^[2] UNESP Sao Paulo State Univ, Sch Dent Araraquara, Dept Oral Diag & Surg, BR-14801903 Araraquara, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: BIOCHEMICAL GENETICS; v. 49, n. 5-6, p. 292-302, JUN 2011.
• Citações Web of Science: 27

Resumo

Interleukin-8 (IL-8), which is responsible for the migration and activation of neutrophils, is an important inflammatory mediator involved in the initiation and amplification of acute inflammatory reactions and chronic inflammatory processes. IL-8 plays an important role in periodontitis, an inflammatory disease characterized by the loss of connective tissue and alveolar bone. The aim of this study was to investigate whether the SNPs rs2227307 (+396) and rs2227306 (+781), and the haplotypes they formed together with the previously investigated rs4073 (-251), were associated with chronic periodontitis susceptibility. Clinical periodontal exams were performed and DNA samples were collected from 493 individuals (223 with periodontitis and 270 controls). Associations between SNPs, haplotypes, and subject phenotypes were analyzed using the chi(2) test followed by multivariate logistic regression modeling. We conclude that the +396TT genotype and the haplotypes ATC/TTC and AGT/TGC were significantly associated with chronic periodontitis susceptibility in Brazilians. (AU)

• Processo FAPESP: 05/03231-7 - Investigação de polimorfismos no promotor do gene interleucina 8 em indivíduos com doença periodontal crônica
• Beneficiário: Yeon Jung Kim
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 03/10424-0 - Investigação de polimorfismos no gene interleucina 8 e seus receptores em indivíduos com doença periodontal crônica
• Beneficiário: Raquel Mantuaneli Scarel Caminaga
• Modalidade de apoio: Auxílio à Pesquisa - Regular