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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Haplotypes in the Interleukin 8 Gene and Their Association with Chronic Periodontitis Susceptibility

Full text
Author(s):
Scarel-Caminaga, Raquel M. [1] ; Kim, Yeon J. [2] ; Viana, Aline C. [2] ; Curtis, Karen M. C. [1] ; Corbi, Samia C. T. [2] ; Sogumo, Patricia M. [1] ; Orrico, Silvana R. P. [2] ; Cirelli, Joni A. [2]
Total Authors: 8
Affiliation:
[1] UNESP Sao Paulo State Univ, Sch Dent Araraquara, Dept Morphol, BR-14801903 Araraquara, SP - Brazil
[2] UNESP Sao Paulo State Univ, Sch Dent Araraquara, Dept Oral Diag & Surg, BR-14801903 Araraquara, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: BIOCHEMICAL GENETICS; v. 49, n. 5-6, p. 292-302, JUN 2011.
Web of Science Citations: 27
Abstract

Interleukin-8 (IL-8), which is responsible for the migration and activation of neutrophils, is an important inflammatory mediator involved in the initiation and amplification of acute inflammatory reactions and chronic inflammatory processes. IL-8 plays an important role in periodontitis, an inflammatory disease characterized by the loss of connective tissue and alveolar bone. The aim of this study was to investigate whether the SNPs rs2227307 (+396) and rs2227306 (+781), and the haplotypes they formed together with the previously investigated rs4073 (-251), were associated with chronic periodontitis susceptibility. Clinical periodontal exams were performed and DNA samples were collected from 493 individuals (223 with periodontitis and 270 controls). Associations between SNPs, haplotypes, and subject phenotypes were analyzed using the chi(2) test followed by multivariate logistic regression modeling. We conclude that the +396TT genotype and the haplotypes ATC/TTC and AGT/TGC were significantly associated with chronic periodontitis susceptibility in Brazilians. (AU)

FAPESP's process: 05/03231-7 - Investigation of polymorphisms in the promoter region of interleukin 8 in Brazilian individuals with chronic periodontitits
Grantee:Yeon Jung Kim
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 03/10424-0 - Investigation of polymorphisms in the promoter region of interleukin 8 in Brazilian individuals with chronic periodontitits
Grantee:Raquel Mantuaneli Scarel Caminaga
Support Opportunities: Regular Research Grants