Chitosan/hydroxypropylmethylcellulose based-mucoadhesive gastroretentive microparticles containing curcumin intended for the prevention of gastric ulcers

Autor(es)

de Souza, Mauricio Palmeira Chaves ; Carvalho, Suzana Gonsalves ; Sposito, Larissa ; de Camargo, Bruna Almeida Furquim ; Bauab, Tais Maria ; Meneguin, Andreia Bagliotti ; Chorilli, Marlus

• Tipo de documento: Artigo Científico
• Fonte: International Journal of Pharmaceutics; v. 674, p. 13-pg., 2025-03-11.

Resumo

Gastric ulcer (GU) is a disease characterized by ulcerative lesions on the surface of the stomach mucosa caused mainly by health-related conditions, non-steroidal anti-inflammatory drugs (NSAIDs) use, and Helicobacter pylori infections. The treatment for this disease requires that the drug remains in contact with the site of action, however, the residence time of conventional dosage forms in this organ is limited due to gastric emptying. Curcumin (CUR) is a compound obtained from the rhizomes of the Curcuma longa plant and has been used in traditional Indian medicine for many centuries. However, its use is limited because it has low solubility in aqueous media. In addition, the treatment of gastric diseases requires the drug to remain in contact with the area, but the residence time of conventional dosage forms in this organ is limited. One strategy to overcome these limitations is the use of a gastroretentive and mucoadhesive delivery system. Therefore, this study aimed to develop polymeric chitosan and hydroxypropylmethylcellulose-based microparticles for the release of CUR and to evaluate their in vivo gastroprotective action. The microparticles had a spherical shape and size between 620 and 820 mu m, and the encapsulation efficiency was over 50 %, with complete release of CUR after 24 h. Thermal analysis showed changes in the structure of the polymers and CUR, suggesting the establishment of new supramolecular interactions. Microparticles showed high bioadhesive forces to the mucin disc. This set of results, suggest that these systems are promising tools for the prevention of gastric lesions associated with the use of NSAIDs, with a gastroprotective index similar to that conferred by omeprazole. (AU)

• Processo FAPESP: 19/25056-5 - Avaliação do potencial de carreadores lipídicos nanoestruturados funcionalizados com CEACAM-1 para incorporação de curcumina no tratamento de infecções por Helicobacter pylori
• Beneficiário: Bruna Almeida Furquim de Camargo
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 22/14075-1 - Sistemas multifuncionais baseados em polissacarídeos para liberação colón específica de pós-bióticos e seu potencial para aplicação no tratamento e prevenção de doenças inflamatórias intestinais
• Beneficiário: Suzana Gonçalves Carvalho
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 14/50928-2 - INCT 2014: Nanotecnologia Farmacêutica: uma abordagem transdisciplinar
• Beneficiário: Maria Vitória Lopes Badra Bentley
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 19/09597-6 - Micropartículas gastrorretentivas contendo nanopartículas de trans resveratrol aplicadas ao tratamento de infecções por Helicobacter pylori
• Beneficiário: Larissa Sposito
• Modalidade de apoio: Bolsas no Brasil - Doutorado