Autor(es)

Filho, Antonio Viana do Nascimento ; Akolkar, Gauri ; Lima, Lara Susan ; Stoyell-Conti, Filipe Fernandes ; Bernardes, Nathalia ; Irigoyen, Maria Claudia ; Singal, Pawan K. ; De Angelis, Katia ; Dias, Danielle da Silva

• Tipo de documento: Artigo Científico
• Fonte: Canadian Journal of Physiology and Pharmacology; v. 103, n. 6, p. 8-pg., 2025-04-30.

Resumo

Doxorubicin is known for its significant cardiotoxicity, in part due to increased oxidative stress (OS). In addition, preclinical models have shown that doxorubicin induces skeletal muscle atrophy. While vitamin C has been recognized as a valuable pharmacological intervention to mitigate cardiac toxicity, its effect on doxorubicin-induced skeletal muscle atrophy remains to be determined. Therefore, the aim of this study was to investigate the effects of vitamin C on skeletal muscle of rats exposed to doxorubicin. Indeed, doxorubicin caused a reduction in body weight and gastrocnemius muscle weight, accompanied by an increase in hydrogen peroxide, protein oxidation, and lipid peroxidation in the gastrocnemius muscle. On the other hand, vitamin C was able to prevent the loss of skeletal muscle mass as well as the increase in markers of OS. In addition, negative correlations were found between gastrocnemius muscle mass and markers of cellular damage. In conclusion, vitamin C appears to be a protective agent against doxorubicin-induced skeletal muscle atrophy and OS. This suggests its potential application as a prophylactic measure for patients undergoing doxorubicin treatment. (AU)

• Processo FAPESP: 18/17183-4 - Sobrecarga de frutose em genitores: impacto do treinamento físico nas alterações cardiometabólicas e neuroimunes da prole
• Beneficiário: Kátia de Angelis Lobo D Avila
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 15/11223-6 - Curso temporal das alterações neuroimunes induzidas pelo consumo crônico de frutose em ratos normotensos e hipertensos: papel do treinamento físico aeróbio
• Beneficiário: Kátia de Angelis Lobo D Avila
• Modalidade de apoio: Auxílio à Pesquisa - Regular