The intelligent podocyte: sensing and responding to a complex microenvironment

Autor(es)

Bertram, John F. ; Cullen-McEwen, Luise A. ; Andrade-Oliveira, Vinicius ; Camara, Niels Olsen Saraiva

• Tipo de documento: Artigo Científico
• Fonte: NATURE REVIEWS NEPHROLOGY; v. 21, n. 7, p. 14-pg., 2025-05-08.

Resumo

Podocytes are key components of the glomerular filtration barrier - a specialized structure that is responsible for the filtration of blood by the kidneys. They therefore exist in a unique microenvironment exposed to mechanical force and the myriad molecules that cross the filtration barrier. To survive and thrive, podocytes must continually sense and respond to their ever-changing microenvironment. Sensing is achieved by interactions with the surrounding extracellular matrix and neighbouring cells, through a variety of pathways, to sense changes in environmental factors such as nutrient levels including glucose and lipids, oxygen levels, pH and pressure. The response mechanisms similarly involve a range of processes, including signalling pathways and the actions of specific organelles that initiate and regulate appropriate responses, including alterations in cell metabolism, immune regulation and changes in podocyte structure and cognate functions. These functions ultimately affect glomerular and kidney health. Imbalances in these processes can lead to inflammation, podocyte loss and glomerular disease. (AU)

• Processo FAPESP: 19/14755-0 - Modulação da microbiota intestinal e do sistema imune pelas células epiteliais intestinais: da homeostase tecidual às doenças
• Beneficiário: Vinicius de Andrade Oliveira
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 23/07482-2 - Detecção de estressores extra e intracelulares por células renais e imunes: novos insights sobre recepção e transdução de sinais e sua relevância para a compreensão de doenças renais
• Beneficiário: Niels Olsen Saraiva Câmara
• Modalidade de apoio: Auxílio à Pesquisa - Temático