| Texto completo | |
| Autor(es): |
Costa, Fabio Figueiredo
;
Chagas, Andrea Karoline Reis
;
Santos, Anna Claudia Monteiro Luz
;
Oliveira, Livia Brito
;
Improta-Caria, Alex Cleber
;
Latado, Adriana Lopes
;
Aras Junior, Roque
Número total de Autores: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | São Paulo Medical Journal; v. 143, n. 3, p. 10-pg., 2025-01-01. |
| Resumo | |
BACKGROUND: Heart failure with reduced ejection fraction (HFrEF) represents a compelling cause of hospital morbidity and mortality in Brazil. There is low adherence to guideline-directed medical therapy (GDMT), which in turn, can result in higher morbidity and mortality. OBJECTIVES: The present study aims to evaluate adherence to GDMT in patients with HFrEF in a Brazilian University hospital service. DESIGN AND SETTINGS: Observational, cross-sectional, single-center study conducted at the Hospital Universit & aacute;rio Professor Edgard Santos (HUPES), Salvador, BA, Brazil. METHODS: The study was conducted with convenience sampling at the cardiology outpatient clinic of a university hospital service. Patients with left ventricular ejection fraction (LVEF) < 40% who had reverse remodeling were excluded. RESULTS: 289 patients were included, with mean age 63 years, 54.7% were male, 56,4% mixed-race and 27,7% had Chagasic cardiomyopathy. 93.1% were prescribed ACEi, ARB or ARNi, 95.8% betablockers, 69.2% spironolactone and 8% the combination hydralazine/isosorbide-dinitrate. 71,7% were using enalapril, losar tan or ARNi above 50% of GDMT target doses; 81,2% were using beta-blockers and 100% were using spironolactone. Only 21,2% were prescribed GDMT target doses ofenalapril, losartan orARNi and 52,3% of beta-blockers. 98,5% of spironolactone prescriptions reached GDMT target doses. CONCLUSIONS: We found high frequencies of prescription of GDMT for HFrEF, considering the therapeutic goals recommended by cardiology guidelines, but, prescription of target doses were low in ACEi, ARB or ARNi and beta-blockers. (AU) | |
| Processo FAPESP: | 22/02339-4 - MicroRNAs regulados pelo treinamento físico como potenciais biomarcadores e terapêuticos da cardiotoxicidade induzida pela doxorrubicina no Câncer de Mama: estudo in vivo, in vitro em cardiomiócitos derivados de iPS e clínico com análise em pacientes |
| Beneficiário: | Alex Cleber Improta Caria |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |